Structural Biologist III

Ambry Genetics Corporation; Aliso Viejo (CA); On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

FSA

PTO

Job summary

Ambry Genetics Corporation, a CAP-accredited and CLIA-licensed molecular genetics laboratory based in Aliso Viejo, California, seeks a Structural Biologist III. The role collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools leveraging structural data to guide clinical decisions.

You will lead a team, mentor staff, and develop novel methods for modeling, dynamics, and clinical variant assessment, while communicating progress to leadership and

Qualifications

• PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.
• Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years post-doc or industrial experience and 2 years management experience.
• Fluency in scripting languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software; strong background in molecular dynamics.

Responsibilities

• Provide structural biology support for variant analyses through structure-function interpretation.
• Develop methods, protocols, and tools for structural modeling, MD, and clinical variant assessment on internal platforms.
• Partner with statisticians and data scientists to validate algorithms and data collection workflows.
• Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.
• Write testable, production-grade code adhering to SDLC standards and code review practices.
• Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.
• Direct and lead the structural team through leadership ensuring timely project completion.
• Inform leadership about project progress and blockers.

Skills

Python

R

Perl

C/C++

Java

SQL

Bioinformatics

Molecular modeling

Education

PhD in computational biology or related field

Tools

Modeling software

MD simulation tools

Job description

Compensation

$120,000 - $170,000

Role Overview

The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.

Key Responsibilities

• Provide structural biology support for variant analyses through structure-function relationship interpretation.
• Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms.
• Partner with statisticians and data scientists to validate algorithms and data collection workflows.
• Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.
• Write testable, production-grade code adhering to SDLC standards and code review best practices.
• Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.
• Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion.
• Support, inform, and educate leadership and stakeholders about project progress and blockers.

Qualifications & Competencies

• Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.
• Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience.
• Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM).

Ambry Genetics Corporation is a CAP-accredited and CLIA-licensed molecular genetics laboratory based in Aliso Viejo, California. We are a genetics-based healthcare company that is dedicated to open scientific exchange so we can work together to understand and treat all human disease faster. At Ambry, everyone is welcome. A career at Ambry Genetics is a chance to be part of a dynamic company that aims to improve health by understanding the relationships between genetics and human disease. We earned our reputation as industry leaders by responsibly introducing cutting-edge genetic testing solutions and continually sharing what we learn with the global scientific community. At Ambry you will be learning, challenging yourself, and having fun while collaborating with teammates through the open exchange of ideas.

Benefits

• Our outstanding benefits program includes medical, dental, vision, FSA, paid sick leave and generous paid time off (PTO) program.
• The Company reserves the right to make changes to the 401k plan from time to time.
• You can learn more about the benefits here.

Ambry Genetics is an Equal Opportunity Employer (EOE) and we maintain a drug-free work environment. The Company believes in second chance employment. Qualified applicants with arrest or conviction history will be considered regardless of their arrest or conviction history, consistent with local laws such as Los Angeles County Fair Chance Ordinance and the California Fair Chance Act. You do not need to disclose your criminal history or participate in a background check until a conditional job offer is made to you. After making a conditional offer and running a background check, if the Company is concerned about conviction that is directly related to the job, you will be given the chance to explain the circumstances surrounding the conviction, provide mitigating evidence, or challenge the accuracy of the background report.

Ambry does not accept unsolicited resumes from individual recruiters, third party recruiting agencies, outside recruiters or firms without an executed contract in place. We are not responsible for any fees related to resumes that are unsolicited or are received by Ambry. Such resumes will be deemed the sole property of Ambry and will be processed accordingly.

To review Ambry’s Privacy Notice, click here: https://www.ambrygen.com/legal/privacy-policy To review the California privacy notice, click here: California Privacy Notice | Ambry Genetics To review the UKG privacy notice, click here: California Privacy Notice | UKG Equal Opportunity Employer This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor. Ambry Genetics Corporation is a CAP-accredited and CLIA-licensed molecular genetics laboratory based in Aliso Viejo, California. We are a genetics-based healthcare company that is dedicated to open scientific exchange so we can work together to understand and treat all human disease faster. At Ambry, everyone is welcome. A career at Ambry Genetics is a chance to be part of a dynamic company that aims to improve health by understanding the relationships between genetics and human disease. We earned our reputation as industry leaders by responsibly introducing cutting-edge genetic testing solutions and continually sharing what we learn with the global scientific community. At Ambry you will be learning, challenging yourself, and having fun while collaborating with teammates through the open exchange of ideas.