Structural Biologist III

Ambry Genetics Corporation; United States; On-site; USD 120,000 - 170,000; Full time

Job summary

Ambry Genetics Corporation seeks a Structural Biologist III to collaborate across biology, bioinformatics and clinical teams to design tools using biomolecular structures to guide clinical decisions. You will interpret structure-function relationships for variant analyses and develop modeling methods for clinical assessment.

The role requires a PhD with 5+ years in computational structural biology, strong scripting (Python/R), and leadership experience to mentor staff and drive projects forward.

Qualifications

• PhD in computational biology, structural biology, biophysics or bioinformatics.
• Minimum 5 years R&D in computational structural biology with leadership
• Proficiency in Python/R and structural modeling tools.

Responsibilities

• Provide structural biology support for variant analyses via structure-function interpretation.
• Develop methods, protocols, and tools for modeling and clinical variant assessment.
• Collaborate with statisticians to validate algorithms and data workflows.
• Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams.
• Write production-grade code and adhere to SDLC standards.
• Maintain documentation, SOPs, and mentor junior staff.
• Direct and lead the structural team to timely project completion.
• Keep leadership informed about progress and blockers.

Skills

Python

R

Perl

C/C++

Java

SQL

Molecular dynamics

Bioinformatics

Education

PhD in computational biology or related field

Tools

PyMOL

GROMACS

Rosetta

Job description

Compensation: $120,000 - $170,000

Role Overview

The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.

Key Responsibilities

• Provide structural biology support for variant analyses through structure-function relationship interpretation.
• Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms.
• Partner with statisticians and data scientists to validate algorithms and data collection workflows.
• Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.
• Write testable, production-grade code adhering to SDLC standards and code review best practices.
• Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.
• Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion.
• Support, inform, and educate leadership and stakeholders about project progress and blockers.

Qualifications & Competencies

• Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.
• Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience.
• Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM).

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Tempus was founded in August of 2015 by Eric Lefkofsky, after his wife was diagnosed with Breast Cancer. Shortly after he founded the company in an effort to bring the power of technology and artificial intelligence to cancer care, he convinced Ryan Fukushima to join as the company’s first employee. Ryan and Eric began assembling a world class team, focused on building the first version of a platform capable of ingesting real time healthcare data in an effort to personalize diagnostics. We built the platform for oncology and have expanded it to neuropsychiatry, cardiology, infectious disease (through COVID), and radiology. Despite our rapid growth, our mission remains the same—to help make sure patients are on the right drug at the right time, so they can live longer and healthier lives. We’re looking for people who can change the world. Who question the status quo and don’t shy away from tough problems. For the builders who are never done building and the learners who are never done learning. We’re looking for passionate people with undying curiosity. Those who want to attack one of the most challenging problems mankind has ever faced. Head on.