Structural Biologist III

Ambry Genetics; Kentucky; On-site; USD 120,000 - 170,000; Full time

Job summary

Ambry Genetics is seeking a Structural Biologist III to collaborate across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies that leverage biomolecular structural data to guide clinical decisions.

You will lead a structural biology team, develop models and workflows, mentor staff, and coordinate cross‑functional projects from concept to production, ensuring rigorous SDLC standards and high‑quality documentation.

Qualifications

• PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.
• Minimum 5 years of R&D experience in computational structural biology with at least 2 years post‑doc or in industry and 2 years of management experience.
• Fluency with scripting languages (Python, R, Perl, C/C++, Java, SQL) and modeling software; strong background in molecular dynamics and experimental techniques (X-ray, Cryo-EM).

Responsibilities

• Provide structural biology support for variant analyses through structure-function interpretation.
• Develop methods, protocols, and tools for structural modeling, MD, and clinical variant assessment on internal platforms.
• Partner with statisticians and data scientists to validate algorithms and data workflows.
• Coordinate cross-functional efforts across Bioinformatics, R&D and reporting teams for clinical projects.
• Write testable, production-grade code adhering to SDLC and code-review best practices.
• Maintain technical docs, SOPs, and knowledge bases; mentor junior staff.
• Direct and lead the structural team to ensure timely project completion.
• Inform leadership about project progress and blockers.

Skills

Python

R

Perl

C/C++

Java

SQL

Molecular dynamics

Cryo-EM

Education

PhD in computational/structural biology

Job description

Role Overview

The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.

Compensation

$120,000 - $170,000

Role Overview

The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.

Key Responsibilities

• Provide structural biology support for variant analyses through structure-function relationship interpretation.
• Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms.
• Partner with statisticians and data scientists to validate algorithms and data collection workflows.
• Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.
• Write testable, production-grade code adhering to SDLC standards and code review best practices.
• Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.
• Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion
• Support, inform, and educate leadership and stakeholders about project progress and blockers.

Qualifications & Competencies

• Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.
• Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience.
• Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM).

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