Staff Scientist

Guidehouse; North Dakota; On-site; USD 120,000 - 160,000; Full time

Benefits offered by this job

Medical, Rx, Dental & Vision Insurance

Parental Leave

401(k) Retirement Plan

Tuition Reimbursement

Employee Referral Program

Learning Opportunities

Job summary

Guidehouse is seeking a Staff Scientist to lead interdisciplinary research for NHLBI, overseeing bench-to-bedside efforts and mentoring the lab team. This full-time, on-site role is based in Bethesda, MD, and requires a PhD with postdoctoral experience, mastery of Zebrafish models, strong publications, and animal model expertise.

The candidate will investigate cellular stress responses, lysosome biology, and opportunities for translational intervention, while presenting findings at conferences

Qualifications

• PhD required with MINIMUM TWO (2) years postdoctoral research in molecular/cellular biology or related field.
• Mastery of Zebrafish models with husbandry, genetic crossing, and genotyping protocols.
• Strong publication record expected.
• Experience with animal models.
• Expertise in cellular biology and advanced microscopy imaging.
• Must be able to obtain and maintain a Federal or DoD Public Trust.

Responsibilities

• Provide laboratory leadership and support for interdisciplinary research.
• Conduct bench-to-bedside studies with NHLBI in Bethesda, MD.
• Investigate stress responses and lysosomal biology.
• Identify potential therapeutic intervention sites for translational research.
• Mentor and train laboratory staff and students.
• Present research at meetings and conferences.
• Collaborate across disciplines to advance initiatives.
• Characterize lysosome roles in physiology and disease.

Skills

Molecular biology

Cellular biology

Biochemistry

Zebrafish models

Publication record

Animal models

Advanced microscopy

Public Trust eligibility

Education

PhD in molecular biology / cellular biology / biochemistry

Tools

Zebrafish husbandry

Genetic crossing

Genotyping protocols

Job description

Job Family:

Scientist

Travel Required:

None

Clearance Required:

Ability to Obtain Public Trust

What You Will Do:

We are currently searching for a Staff Scientist to provide laboratory leadership and support services to perform interdisciplinary and collaborative research from bench to beside with the National Heart, Lung, and Blood Institute (NHLBI). This is a full-time, on-site opportunity in Bethesda, MD.

• Combine biochemical, molecular, cellular, genetic, and quantitative approaches to investigate fundamental biological processes across a range of organisms, including fish, flies, mice, mammals, microbes, and viruses.

• Research how cells sense, respond, and adapt to a variety of stress conditions, including nutrient deprivation, organelle damage, and pathogen infection.

• Address how alterations in mTOR, TFEB, TFE3, and lysosomal function lead to human disease.

• Seek to identify potential sites for therapeutic intervention suitable for further evaluation in translational and clinical research efforts.

• Serve as laboratory lead contributing to training and mentoring of all laboratory members.

• Present research at meetings and conferences.

• Work in an interdisciplinary lab collaborating with others to advance research initiatives.

• Characterize the contribution of lysosomes to a variety of physiological processes, both in normal and pathological conditions.

What You Will Need:

• PhD with MINIMUM TWO (2) years of postdoctoral research experience in molecular biology, cellular biology, biochemistry, or related field.

• Must have a mastery of Zebrafish models with skills such as husbandry, genetic crossing, and genotyping protocols.

• Must have a have a strong publication record.

• Experience working with animal models.

• Expertise in cellular biology and advanced microscopy imaging.

• Must be able to obtain and maintain a Federal or DoD Public Trust. Candidates must receive approved adjudication of their Public Trust prior to onboarding with Guidehouse. Candidates with an active Public Trust or existing suitability are preferred.

What Would Be Nice To Have:

• Knowledge of organelle cell biology (lysosomes, autophagy, intracellular trafficking), and a commitment to conducting related high-quality research.

• Able to work independently and in a team setting.

• Excellent oral and written communication abilities.

• Outstanding interpersonal and time management skills.

• Demonstrated experience in staff training and mentoring.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at [e-mail]. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or [e-mail]. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse's Ethics Hotline. If you want to check the validity of correspondence you have received, please contact [e-mail]. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.