Staff Scientist

Guidehouse; McLean (VA); On-site; USD 110,000 - 150,000; Full time

Benefits offered by this job

Medical, Rx, Dental & Vision Insurance

401(k) Retirement Plan

Tuition Reimbursement, Personal Dev.

Parental Leave

Transit and Parking Commuter Benefits

Job summary

Guidehouse is seeking a Staff Scientist to lead interdisciplinary research for NHLBI collaborations in Bethesda, MD. The role integrates biochemical, molecular, cellular, genetic, and quantitative approaches across organisms to study stress responses and lysosomal biology.

The candidate will mentor laboratory members, present findings at conferences, and work in a collaborative team to translate basic biology into potential therapeutic insights.

Qualifications

• PhD with at least 2 years postdoc in molecular/cellular biology or related field.
• Expertise with Zebrafish models including husbandry, crosses and genotyping protocols.
• Strong publication record across relevant fields.
• Experience working with animal models.
• Expertise in cellular biology and advanced microscopy imaging.

Responsibilities

• Provide laboratory leadership and support for interdisciplinary research from bench to bedside.
• Combine biochemical, molecular, cellular, genetic and quantitative approaches across organisms.
• Investigate how cells sense stress and how mTOR, TFEB, TFE3 and lysosomal function relate to disease.
• Mentor and train laboratory members; present research at meetings.
• Collaborate in an interdisciplinary lab to advance research initiatives.
• Characterize lysosome contributions in physiology and pathology.

Skills

Zebrafish

Microscopy

Genotyping

Molecular biology

Cell biology

Scientific writing

Education

PhD in biology or related field

Job description

Job Family:ScientistTravel Required:NoneClearance Required:Ability to Obtain Public TrustWhat You Will Do:We are currently searching for a Staff Scientist to provide laboratory leadership and support services to perform interdisciplinary and collaborative research from bench to beside with the National Heart, Lung, and Blood Institute (NHLBI). This is a full-time, on-site opportunity in Bethesda, MD.Combine biochemical, molecular, cellular, genetic, and quantitative approaches to investigate fundamental biological processes across a range of organisms, including fish, flies, mice, mammals, microbes, and viruses.Research how cells sense, respond, and adapt to a variety of stress conditions, including nutrient deprivation, organelle damage, and pathogen infection.Address how alterations in mTOR, TFEB, TFE3, and lysosomal function lead to human disease.Seek to identify potential sites for therapeutic intervention suitable for further evaluation in translational and clinical research efforts.Serve as laboratory lead contributing to training and mentoring of all laboratory members.Present research at meetings and conferences.Work in an interdisciplinary lab collaborating with others to advance research initiatives.Characterize the contribution of lysosomes to a variety of physiological processes, both in normal and pathological conditions.What You Will Need:PhD with MINIMUM TWO (2) years of postdoctoral research experience in molecular biology, cellular biology, biochemistry, or related field.Must have a mastery of Zebrafish models with skills such as husbandry, genetic crossing, and genotyping protocols.Must have a have a strong publication record.Experience working with animal models.Expertise in cellular biology and advanced microscopy imaging.Must be able to obtain and maintain a Federal or DoD Public Trust. Candidates must receive approved adjudication of their Public Trust prior to onboarding with Guidehouse. Candidates with an active Public Trust or existing suitability are preferred.What Would Be Nice To Have:Knowledge of organelle cell biology (lysosomes, autophagy, intracellular trafficking), and a commitment to conducting related high-quality research.Able to work independently and in a team setting.Excellent oral and written communication abilities.Outstanding interpersonal and time management skills.Demonstrated experience in staff training and mentoring.What We Offer:Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.Benefits include:Medical, Rx, Dental & Vision InsurancePersonal and Family Sick Time & Company Paid HolidaysParental Leave401(k) Retirement PlanGroup Term Life and Travel AssistanceVoluntary Life and AD&D InsuranceHealth Savings Account, Health Care & Dependent Care Flexible Spending AccountsTransit and Parking Commuter BenefitsShort-Term & Long-Term DisabilityTuition Reimbursement, Personal Development, Certifications & Learning OpportunitiesEmployee Referral ProgramCorporate Sponsored Events & Community OutreachCare.com annual membershipEmployee Assistance ProgramSupplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)Position may be eligible for a discretionary variable incentive bonusAbout GuidehouseGuidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at [e-mail]. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or [e-mail]. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact [e-mail]. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.