SRE Manager: Cloud Reliability & Observability

Twist Bioscience Corporation; San Francisco (CA); Hybrid; USD 210,000 - 243,000; Full time

Job summary

Twist Bioscience Corporation seeks an experienced Manager, Site Reliability Engineering to lead Site Operations and infrastructure initiatives in a hybrid role based in South San Francisco. You will drive reliability, scalability, and security across cloud platforms and critical applications.

You will collaborate with engineering teams to improve deployment processes, implement CI/CD, and foster a culture of reliability while mentoring SRE engineers.

Qualifications

• 5–7+ years of experience in Site Operations, Site Reliability Engineering, Infrastructure Engineering, or related operational roles.
• Prior experience leading or mentoring engineering or operations teams.
• Strong hands‑on experience with cloud infrastructure platforms (AWS, Azure, and/or GCP).
• Experience managing Kubernetes (K8s) environments in production.
• Strong understanding of networking concepts including DNS, load balancing, firewalls, routing, and CDN technologies.
• Experience with Akamai CDN administration and optimization.
• Experience with observability and monitoring platforms, including Splunk.
• Experience with storage infrastructure and cloud-native storage solutions.
• Strong scripting and automation experience (Python, Bash, Terraform, or similar).
• Experience implementing and maintaining CI/CD pipelines.
• Strong troubleshooting and incident management skills in complex distributed systems.
• Excellent communication and cross‑functional collaboration skills.

Responsibilities

• Lead and manage the Site Operations / SRE function.
• Own cloud infrastructure architecture, operations, scalability, and optimization.
• Ensure high availability and reliability of production applications and services.
• Drive operational excellence through automation, monitoring, and incident management.
• Develop and maintain observability platforms including logging, metrics, alerting, and tracing.
• Manage Kubernetes-based infrastructure and container orchestration environments.
• Oversee networking, DNS, CDN, and storage infrastructure across cloud environments.
• Collaborate with software engineering teams to improve deployment processes, system resilience, and performance.
• Establish and improve CI/CD pipelines and infrastructure-as-code practices.
• Lead incident response, root cause analysis, and post-incident remediation efforts.
• Manage vendor and platform relationships where applicable.
• Mentor and develop SRE / Site Operations engineers and foster a culture of reliability and continuous improvement.
• Define and implement infrastructure security and compliance best practices.

Skills

Leadership

Cross-functional collaboration

Incident management

Cloud infrastructure

Observability

Tools

Kubernetes

Akamai CDN

Splunk

Terraform

Python

Bash

Job description

Twist Bioscience Corporation seeks an experienced Manager, Site Reliability Engineering to lead Site Operations and infrastructure initiatives in a hybrid role based in South San Francisco. You will drive reliability, scalability, and security across cloud platforms and critical applications.

You will collaborate with engineering teams to improve deployment processes, implement CI/CD, and foster a culture of reliability while mentoring SRE engineers.