SRE Manager - Cloud Reliability Leader (Hybrid)

Twist Bioscience Corporation; South San Francisco (CA); Hybrid; USD 210,000 - 243,000; Full time

Job summary

Twist Bioscience Corporation in South San Francisco is recruiting an experienced SRE Manager to lead Site Operations and ensure reliability of cloud infrastructure and critical applications.

You will drive automation, observability, and platform reliability across Kubernetes, DNS, CDN, and storage, partnering with software engineers to improve deployment and resilience. Strong leadership and security mindset are essential.

Qualifications

• 5–7+ years in Site Operations, SRE, or related roles.
• Experience leading engineering or operations teams.
• Hands-on cloud infrastructure experience (AWS/Azure/GCP).
• Production Kubernetes management experience.
• Strong networking knowledge including DNS, load balancing, and CDN tech.
• Observability/monitoring experience (Splunk).
• Scripting and automation with Python, Bash, Terraform.
• Experience building CI/CD pipelines and IaC practices.
• Excellent cross-functional collaboration.

Responsibilities

• Lead and manage the Site Operations / SRE function.
• Own cloud infrastructure architecture, operations, and optimization.
• Ensure high availability and reliability of production apps.
• Drive automation, monitoring, and incident management.
• Develop observability platforms with logging, metrics, alerts, and tracing.
• Manage Kubernetes-based infrastructure and container orchestration.
• Oversee DNS, CDN, storage across cloud environments.
• Collaborate with engineering to improve deployment and resilience.
• Establish CI/CD pipelines and IaC practices.
• Lead incident response and post-incident remediation.
• Mentor SRE engineers and foster reliability culture.
• Define security and compliance best practices.

Skills

Cloud platforms AWS/Azure/GCP

Kubernetes

Networking & CDN

Observability (Splunk)

Python scripting

Terraform (IaC)

CI/CD pipelines

Incident management

Leadership/mentoring

Security/compliance

Tools

Akamai CDN

Splunk

Job description

Twist Bioscience Corporation in South San Francisco is recruiting an experienced SRE Manager to lead Site Operations and ensure reliability of cloud infrastructure and critical applications.

You will drive automation, observability, and platform reliability across Kubernetes, DNS, CDN, and storage, partnering with software engineers to improve deployment and resilience. Strong leadership and security mindset are essential.