Specialist Positions - Roybal Lab

University of California - San Francisco; San Francisco (CA); On-site; USD 55,000 - 194,800; Full time

Job summary

The University of California - San Francisco is seeking a Specialist to contribute to early-stage pre-clinical development of T cell therapeutic circuits for treating Sarcomas.

Responsibilities include performing experimental work, developing assays, and compiling results. Ideal candidates will possess qualifications ranging from a Baccalaureate degree to a terminal degree, plus relevant research experience.

Salary range is approximately $55,000 – $194,800.

Qualifications

• Baccalaureate degree or equivalent or at least four years of research experience.
• Master’s degree or a baccalaureate degree with 3 or more years of research experience.
• Master’s degree (or equivalent) or five to ten years of experience in the relevant specialization.
• Terminal degree (or equivalent) or ten or more years of experience in the relevant specialization.

Responsibilities

• Perform experimental work on protein engineering and primary human T cell culture.
• Develop novel assays and design in-vitro T cell circuits.
• Compile pre-clinical results to support clinical vector design.

Skills

Primary immune cell culture

Tumor cell culture

Flow cytometry

Experimental design and data analysis

Tumor and T cell injections

Tumor growth measurements

Collection of T cells and tumor cells

Education

Baccalaureate degree or equivalent

Master’s degree

Terminal degree or equivalent

Tools

Multi-colored flow cytometry

Incucyte

Job description

Position Overview

The mission of the UCSF Sarcoma Initiative is to support the development of the next generation of cellular therapies to treat this disease. In the Roybal Lab, we engage in translational research in partnership with research groups at UCSF to develop cutting‑edge engineered T cell therapeutics and prepare them for the clinic, as well as develop novel cell technologies for future therapeutic solutions.

We are seeking applications for a Specialist to contribute to early‑stage pre‑clinical development of novel T cell therapeutic circuits for the treatment of Sarcomas. This work will range from proof‑of‑concept studies to IND enabling studies for a phase I clinical trial. This is an excellent opportunity to learn cutting‑edge engineered T cell cancer therapy from leading experts in the field and gain highly sought after pre‑clinical development experience in the field of cell therapy.

Responsibilities

• Perform experimental work on protein engineering, primary human T cell culture, viral and non‑viral transductions, and mouse tumor models.
• Develop novel assays.
• Design and validate in‑vitro T cell circuits.
• Establish in‑vivo tumor models.
• Compile pre‑clinical results to support the designation of clinical vector design.
• Contribute to the in‑vitro and in‑vivo pharmacology characterization of therapeutic product candidates in collaboration with a process development team towards an IND filing.
• Work with other staff in the Roybal Lab and collaborators in developing the necessary assays, protocols and SOPs; execute the experimental work, analyze data, and report findings in presentations and progress reports.

Required Qualifications

• Junior Specialist – Baccalaureate degree (or equivalent) or at least four years of research experience.
• Assistant Specialist – Master’s degree or a baccalaureate degree with 3 or more years of research experience.
• Associate Specialist – Master’s degree (or equivalent) or five to ten years of experience in the relevant specialization.
• Full Specialist – terminal degree (or equivalent) or ten or more years of experience in the relevant specialization.
• Primary immune cell culture.
• Tumor cell culture.
• Flow cytometry.
• Experimental design and data analysis.
• Tumor and T cell injections.
• Tumor growth measurements (bioluminescence or caliper).
• Collection of T cells and tumor cells from mouse blood, tissues, and tumors.

Preferred Qualifications

• Multi‑colored flow cytometry and cell sorting experience.
• T cell assay experience (ELISAs, proliferation, cytotoxicity by Incucyte, etc.).
• Human immune cell engineering with viral and non‑viral approaches.
• Experience contributing to translational projects and/or INDs.
• Experience creating and giving data presentations.

Application Requirements

Document requirements:

• Curriculum Vitae – CV must clearly list current and/or pending qualifications (e.g., board eligibility/certification, medical licensure, etc.).

Reference requirements:

• 3 required (contact information only).

See Table 24B for the salary range for this position. A reasonable estimate for this position is $55,000 – $194,800.

Equal Opportunity Employment

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.

Location

San Francisco, CA