Senior Translational Biologist — In Vivo & Imaging Expert

Pioneering Medicines; Cambridge (MA); Presencial; USD 126.000 - 165.000; Jornada completa

Descripción de la vacante

FL106 Inc. in Cambridge, MA is seeking a Senior/ Scientist to advance translational biology programs with expertise in flow cytometry, primary cell isolation, and imaging.

The role involves designing preclinical studies, leading multi-parameter cytometry, tissue dissociation, and applying siRNA approaches to validate targets. Collaboration and mentoring are essential in a fast-paced setting.

Formación

• PhD in Molecular Biology or related field with 3–6+ years of experience, or MS with significant experience.
• Strong expertise in flow cytometry, panel design, troubleshooting and data analysis.
• Hands-on experience with primary cell isolation from mouse tissue and MACS/FACS.
• Hands-on microscopy and image analysis using software like ImageJ/Fiji or Imaris.

Responsabilidades

• Design, execute, and analyze complex in vitro / in vivo experiments to support research programs.
• Lead and perform multi-parameter flow cytometry assays, including panel design, optimization, and data interpretation.
• Perform and optimize primary cell isolation from tissues, including enzymatic and mechanical tissue dissociation, MACS, and FACS.
• Perform and interpret microscopy-based assays, including high-content microscopy, immunofluorescence, confocal, and intravital imaging.
• Support mouse studies as needed, including disease models, dosing, tissue collection, and phenotypic analysis.
• Develop and apply siRNA-based approaches for target validation and mechanistic studies.
• Analyze and interpret data, generate reports, and present findings to cross-functional teams.
• Collaborate with internal and external stakeholders to advance project goals.
• Mentor junior scientists and contribute to a collaborative team environment.
• Maintain accurate experimental records and ensure compliance with institutional and regulatory guidelines.

Conocimientos

Flow cytometry

FACS

Cell sorting

Panel design

Data analysis

FlowJo

Educación

Ph.D. in Molecular Biology, Cell Biology, or a related field

M.S. with significant experience

Herramientas

ImageJ/Fiji

Imaris

MACS

FACS

Descripción del empleo

FL106 Inc. in Cambridge, MA is seeking a Senior/ Scientist to advance translational biology programs with expertise in flow cytometry, primary cell isolation, and imaging.

The role involves designing preclinical studies, leading multi-parameter cytometry, tissue dissociation, and applying siRNA approaches to validate targets. Collaboration and mentoring are essential in a fast-paced setting.