Senior System Engineer

MantaBio; Beverly (MA); On-site; USD 90,000 - 120,000; Full time

Job summary

Join an early-stage startup as a Lead Systems Engineer, where you'll integrate various components into a high-performance PCR platform. This role demands deep technical fluency and a hands-on approach to drive product development from prototype to commercial readiness. Collaborate across disciplines to ensure seamless integration, while leveraging your experience in systems engineering and CAD proficiency.

Benefits

Health Insurance

Dental Insurance

Vision Insurance

401(k)

Qualifications

• 6 - 10 years of experience as a systems engineer in hardware-focused environments.
• Proficiency in CAD and one or more data analysis environments.

Responsibilities

• Integrate mechanical, electrical, fluidic, optical, and consumable components.
• Design and build electromechanical subsystems.
• Analyze experimental data to inform iterative design.

Skills

Systems Integration

Prototyping

Cross-Functional Collaboration

Hands-on mindset

Education

MS in Engineering

Tools

CAD

Python

MATLAB

Job description

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MantaBio is an early-stage startup redefining how microbial contamination is detected in biopharma manufacturing. Our fully automated, sample-to-answer PCR platform merges microfluidics, optics, thermal control, embedded electronics, and software into one compact, high-performance device. With strong pull from major industry players, we’re on the cusp of something transformative — and we’re building the core team to get us there.

Why This Role Matters

As Lead Systems Engineer, you’ll be instrumental in integrating mechanical, electrical, fluidic, optical, and consumable components into a cohesive platform. You’ll help drive the development of a complex, fully integrated product — transitioning from prototype to commercial readiness. This role requires deep technical fluency, cross-disciplinary thinking, and a hands-on approach.

What You’ll Do

• Systems Integration and Prototyping
• Design and build electromechanical subsystems, including fluid handling, thermal cycling, and optical detection.
• Develop breadboards and alpha prototypes to mitigate technical risk prior to commercial development.
• Integrate pumps, valves, manifolds, heaters, sensors, and optics into reliable systems.
• Design & Development
• Use CAD (SolidWorks preferred) for mechanical design and support prototyping via CNC machining, 3D printing, or injection molding.
• Analyze experimental data to inform iterative design (bonus points for Python or MATLAB fluency).
• Cross-Functional Collaboration
• Partner with software, biology, chemistry, and electronics teams to ensure seamless integration.

What You Bring

• 6 - 10 years of experience as a systems engineer in hardware-focused environments.
• MS in Engineering preferred but not required.
• Proficiency in CAD and one or more data analysis environments (Python, MATLAB, etc.).
• Hands-on, self-directed, and execution-driven mindset.

What We Offer

• Benefits: Health, dental, vision, and 401(k)

To apply for the Lead Systems Engineer position, please send your resume along with a cover letter to [e-mail].

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Industries

  Medical Equipment Manufacturing

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Inferred from the description for this job

Medical insurance

Vision insurance

401(k)

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