Senior Scientist, Waltham, MA

BPGbio, Inc.; Waltham (MA); On-site; USD 120,000 - 150,000; Full time

Job summary

BPGbio, Inc. is seeking a highly motivated Senior Scientist in Proteomics to join their Translational Research team in Waltham, MA. This role focuses on advancing novel therapeutic assets across various diseases such as rare mitochondrial disorders and oncology.

The ideal candidate will lead biomarker discovery and drive mechanism-of-action studies while collaborating closely with cross-functional teams. A Ph.D. in a relevant field and significant experience in mass spectrometry-based proteomics are key requirements.

Qualifications

• 4+ years of industry experience in proteomics or translational biomarker research (biotech or pharmaceutical environment preferred).
• Strong hands-on expertise in mass spectrometry–based proteomics.
• Experience integrating proteomics with multi-omics datasets is desired.

Responsibilities

• Design and execute discovery and targeted proteomics experiments.
• Lead analysis of complex biological samples using proteomics platforms.
• Collaborate closely with biology, pharmacology, and bioinformatics teams.

Skills

Mass spectrometry–based proteomics

Biomarker discovery

Data analysis

Collaboration with interdisciplinary teams

Education

Ph.D. in Proteomics, Biochemistry, Molecular Biology, or related field

Tools

LC-MS/MS platform

Job description

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Senior Scientist

Full Time Waltham, MA, US

5 days ago Requisition ID: 1233

Salary Range: $120,000.00 To $150,000.00 Annually

NO AGENCIES - PLEASE!

POSITION SUMMARY:

We are seeking a highly motivated Senior Scientist, Proteomics to join our Translational Research team and play a central role in advancing a novel therapeutic asset across rare mitochondrial disorders, neurological diseases, oncology, and other indications. This individual will be a key driver of mechanism‑of‑action (MoA) studies, biomarker discovery/validation, enabling data‑driven decision‑making across preclinical and clinical development.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Design and execute discovery and targeted proteomics experiments to support MoA, pharmacodynamics, and biomarker identification.
• Lead analysis of complex biological samples (plasma, tissue, CSF, cellular systems) using LC‑MS/MS–based proteomics platforms.
• Drive biomarker discovery and validation, translating proteomic findings into clinically relevant biomarker candidates.
• Collaborate closely with biology, pharmacology, bioinformatics, and clinical teams to support translational research strategy.
• Interpret and present results to cross‑functional teams, and external collaborators.
• Contribute to regulatory and publication‑quality documentation, including study reports and manuscripts.
• Stay current with advances in proteomics technologies, computational tools, and analytical methods to continuously improve platform capabilities.
• Other duties, as assigned.

QUALIFICATIONS:

• Ph.D. in Proteomics, Biochemistry, Molecular Biology, Analytical Chemistry, or a related field.
• 4+ years of industry experience in proteomics or translational biomarker research (biotech or pharmaceutical environment preferred).
• Strong hands‑on expertise in mass spectrometry–based proteomics.
• Ability to work with an interdisciplinary team of biologists, chemists, and computational scientists to deeply characterize and understand the proteomes of cells, biofluids, and tissues.
• Demonstrated ability to analyze, interpret and present data in a clear fashion.
• Experience integrating proteomics with multi‑omics datasets and systems biology approaches is desired.
• Solid scientific training/productivity as identified through high‑impact publications demonstrating creative thinking as well as innovative technical approaches.