Scientist – Metabolomics/Lipidomics, Waltham, MA

BPGbio, Inc.; Waltham (MA); On-site; USD 105,000 - 115,000; Full time

Job summary

BPGbio, Inc. in Waltham, MA is seeking a Metabolomics/Lipidomics Scientist to lead MS-based bioanalysis and method development. The role emphasizes targeted and non-targeted analyses, software-assisted data reporting, and collaboration with external partners.

The candidate will apply LC/MS and LC/MS/MS workflows to metabolite analysis across biological matrices, and will contribute to SOP development and QA/QC processes within a multidisciplinary translational sciences platform.

Qualifications

• The candidate must hold a Ph.D. in analytical chemistry, biochemistry, or a related field with 1+ year experience.
• Broad understanding of metabolomics/lipidomics applications and biochemistry related to systems biology, neurodegeneration, obesity, cardiovascular disease, and cancer is a plus.
• Proven ability to troubleshoot instrumentation issues for HPLC and MS systems.
• Experience with sample preparation techniques including SPE, liquid-liquid extraction and protein precipitation.
• Deep understanding of core HPLC and MS concepts (reversed-phase LC, HILIC, high-res/accurate mass, MS/MS).
• Excellent communication and teamwork, with strong record-keeping and ability to work independently.

Responsibilities

• Conceptualize, perform, analyze and report experiments.
• Perform mass spectrometry-based assays and metabolite analysis on diverse samples.
• Laboratory analytical instrumentation routine maintenance.
• Daily QA/QC, system suitability testing, method development and validated SOP implementation.
• Develop SOPs and manage external collaborations.
• Other duties as assigned.

Skills

Mass spectrometry

LC/MS

Method development

SOP development

Team collaboration

Bioanalysis

HILIC

Reversed-phase HPLC

MS/MS

Isotope dilution

Mass spectrometry troubleshooting

SPE

Liquid-liquid extraction

Protein precipitation

Metabolomics

Lipidomics

Education

Ph.D. in analytical chemistry/biochemistry or related field

Job description

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Scientist

Platform & Translational Sciences Full Time Waltham, MA, US

30+ days ago Requisition ID: 1238

Salary Range: $105,000.00 To $115,000.00 Annually

POSITION SUMMARY:

The Metabolomics/Lipidomics Scientist will have extensive experience in metabolite and/or small molecule analysis using LC/MS and LC/MS/MS platforms. The scientist will perform targeted and nontargeted bioanalysis and develop novel methods to support the platform.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Responsible for the full spectrum of activities involved in metabolomics/lipidomics analysis as a member of the team including the following:
• Conceptualize, perform, analyze and report experiments.
• Perform mass spectrometry-based assays and studies focused on metabolite analysis of diverse samples from the biological matrices.
• Laboratory analytical instrumentation routine maintenance.
• Daily QA/QC, system suitability testing, method development and validated SOP implementation
• Develop SOPs.
• Manage external collaborations.
• Other duties, as assigned.

QUALIFICATIONS:

• Ph.D. (with 1+ years of experience) in analytical chemistry, biochemistry, or a related field in the analysis of small molecules and metabolites by mass spectrometry.
• Broad understanding of metabolomics/lipidomics applications and biochemistry in the areas of systems biology, neurodegeneration, obesity, cardiovascular disease, and cancer is a plus.
• Proven ability to troubleshoot common instrumentation-related issues, specifically for HPLC and MS systems.
• Experience with common sample preparation techniques, including solid phase extraction (SPE), liquid-liquid extraction and protein precipitation for biofluids, tissues and cells.
• Deep understanding of core HPLC and MS concepts, including (but not limited to) principles of reversed-phase LC and HILIC, high-resolution/accurate mass strategies, structural elucidation by MS/MS, isotope dilution, isotopologue identification, multiple-charged ions.
• Excellent communication and interpersonal skills combined with a proven track record of technical and organizational skills.
• Must be able to work in a team-oriented environment and demonstrate attention to detail and record-keeping. Must demonstrate fully professional level requiring independent work in metabolomics research and development.
• Knowledge of Microsoft Word, Excel, and PowerPoint required for preparation of reports to management.
• Ability to prepare manuscripts for presentation, publication in scientific journals, and regulatory requirements is preferred.