Senior Scientist, Translational PK/PD

Scorpion Therapeutics; Boston (MA); On-site; USD 129,000 - 203,000; Full time

Benefits offered by this job

Annual bonus

Medical/dental/vision insurance

401(k) retirement plan

Job summary

Scorpion Therapeutics in Boston seeks a Translational PK/PD Senior Scientist to drive model-informed decisions across drug discovery and dose prediction. The role integrates PKPD modeling with experimental data, supporting forward and reverse translation and informing modality selection.

You will build PKPD, PBPK, and QSP platforms, design studies, and contribute to automated workflows. Collaboration with multidisciplinary teams will advance candidate optimization and human dose projection

Qualifications

• Education: Master’s (3+ years), PharmD (1 year), or Ph.D. in pharmacokinetics/pharmacodynamics, mathematics, applied mathematics, systems/computational biology, chemical/biomedical engineering, statistics/biostatistics, or related field.
• Hands-on translational PKPD modeling using standard software (e.g., Matlab, OSP Suite, Monolix, R).
• Strong experimental design, mathematical problem solving, critical data analysis/interpretation, and/or statistics.

Responsibilities

• Serve as PK/PD modeler in cross-functional teams to support model-informed decisions on drug discovery, modality selection, and dose prediction.
• Integrate in vitro and in vivo data to build PKPD, PBPK, QSP, and other mechanistic modeling platforms to support forward/reverse translation.
• Collaborate to design experimental studies and modeling plans to identify and optimize drug candidates.
• Collaborate on automated workflows for implementing modeling platforms to inform human PK/PD and dose projections.
• Build expertise and leadership in translational modeling and drug discovery (with guidance from experienced modelers).

Skills

Translational PKPD modeling

Mathematical problem solving

Experimental design

Statistics

Modeling software: Matlab

Modeling software: Monolix

Modeling software: R

Modeling software: OSP Suite

Education

Master's/PhD in PKPD or related field

Tools

Matlab

Monolix

OSP Suite

R

Job description

The Translational PK/PD Senior Scientist will:

• Serve as PK/PD modeler in cross-functional teams to support model-informed decisions on drug discovery, modality selection, and dose prediction.
• Integrate in vitro and in vivo data to build PKPD, PBPK, QSP, and other mechanistic modeling platforms to support forward/reverse translation.
• Collaborate to design experimental studies and modeling plans to identify and optimize drug candidates.
• Collaborate on automated workflows for implementing modeling platforms to inform human PK/PD and dose projections.
• Build expertise and leadership in translational modeling and drug discovery (with guidance from experienced modelers).

Qualifications

• Education: Master’s (3+ years), PharmD (1 year), or Ph.D. in pharmacokinetics/pharmacodynamics, mathematics, applied mathematics, systems/computational biology, chemical/biomedical engineering, statistics/biostatistics, or related field.

Required Experience/Skills

• Hands-on translational PKPD modeling using standard software (e.g., Matlab, OSP Suite, Monolix, R).
• Strong experimental design, mathematical problem solving, critical data analysis/interpretation, and/or statistics.

Preferred Experience/Skills

• Modeling experience informing discovery/development decisions for biologics, protein therapeutics, and/or peptides.
• Interdisciplinary teamwork and collaborative problem solving.
• Expertise developing novel PKPD/PBPK/QSP (or related) mechanistic approaches.

Benefits/Pay (as stated)

• Annual bonus and long-term incentive (if applicable).
• Medical/dental/vision, retirement (401(k)), paid holidays, vacation, compassionate and sick days.
• Salary range: $129,000.00–$203,100.00.