Senior Scientist, Translational PK/PD

Scorpion Therapeutics; Pennsylvania; On-site; USD 120,000 - 180,000; Full time

Job summary

Scorpion Therapeutics is seeking a Senior Scientist in Translational PK/PD within the PDMB to guide drug discovery for biologics, proteins, and peptides. The role designs and executes modeling analyses and integrates diverse data to inform dose and modality decisions.

You will collaborate across cross-functional teams, build mechanistic PK/PD platforms (PKPD, PBPK, QSP), and contribute to automated workflows and leadership in translational modeling.

Qualifications

• Hands-on translational PKPD modeling using MATLAB, OSP Suite, Monolix, or R.
• Experimental design, mathematical problem solving, and data analysis/interpretation.

Responsibilities

• Serve as PK/PD modeler in cross-functional teams to guide dose predictions.
• Integrate in vitro and in vivo data to build PKPD, PBPK, QSP or other platforms.
• Collaborate with PDMB and Discovery/Translational teams to design studies and plans.
• Lead on automated workflows for modeling platforms informing human PK/PD projections.
• Develop leadership and communicate effectively within translational modeling context.

Skills

PK/PD modeling

Translational modeling

Biostatistics

Data analysis

Interdisciplinary collaboration

MATLAB

R

PKPD modeling

Education

MS/PhD in pharmacokinetics/pharmacodynamics or related field

PharmD

Tools

MATLAB

OSP Suite

Monolix

R

Job description

The department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) is seeking a Senior Scientist for its Translational PK/PD organization. The role designs and executes analyses, guiding drug discovery strategy focused on biologics, protein therapeutics, and peptides.

The Translational PK/PD Senior Scientist will:

• Serve as PK/PD modeler in cross-functional teams to make model-informed decisions about drug discovery, modality selection, and dose prediction.
• Integrate in vitro and in vivo data to build PKPD, PBPK, QSP, or other mechanistic modeling platforms for drug disposition and pharmacology.
• Collaborate with PDMB and Discovery/Translational teams to design experimental studies and modeling plans to identify and optimize drug candidates.
• Collaborate on automated workflows for implementing modeling platforms to inform human PK/PD and dose projections.
• With guidance, build expertise and leadership in translational modeling and drug discovery; demonstrate strong communication and leadership skills.

Qualifications:

• Master’s (3+ years), PharmD (1 year), or Ph.D. in pharmacokinetics/pharmacodynamics, mathematics, applied mathematics, systems biology, computational biology, chemical/biomedical engineering, statistics/biostatistics or related field, with increasing responsibility/independence.

Required experience/skills:

• Hands-on translational PKPD modeling using Matlab, OSP Suite, Monolix, or R.
• Experimental design, mathematical problem solving, and critical data analysis/interpretation and/or statistics.

Preferred experience/skills:

• Modeling experience informing discovery/development of biologics/protein therapeutics/peptides.
• Interdisciplinary teamwork.
• Expertise developing novel PKPD, PBPK, QSP, or related mechanistic approaches.

Skills:

Biostatistics, data analysis, data modeling, data science, drug discovery process, interdisciplinary collaboration, MATLAB, pharmacodynamics/pharmacokinetics, PKPD modeling, statistical analysis.