Senior Scientist, Targeted Protein Degradation & E3 Ligases

Amgen; Thousand Oaks (CA); Hybrid; USD 127,000 - 172,000; Full time

Benefits offered by this job

Total Rewards Plan

Health, dental, vision benefits

Stock-based incentives

Flexible work models

Retirement and Savings Plan

Paid time off

Job summary

Amgen Inc. (IR) in Thousand Oaks, CA, seeks a Senior Scientist to advance E3 ligase-focused molecular glue screening and drive target discovery within the Induced Proximity Platform (IPP).

You will validate hits, characterize mechanisms, and translate findings into therapeutic opportunities across oncology, inflammation, and rare disease contexts. The role requires a PhD in a relevant field with postdoctoral/industry experience; you will work across biology, chemistry, proteomics, and research

Qualifications

• > Doctorate in Molecular Biology, Biochemistry, Chemical Biology, Cell Biology or related field.
• > 1–2 years of postdoctoral/industry experience preferred.
• > Experience with induced proximity or molecular glue concepts is desirable.

Responsibilities

• Design and execute workflows to validate molecular glue screening hits, including mechanism characterization and understanding of target biology.
• Evaluate molecular glue hits in disease-relevant models to identify novel targets and therapeutic opportunities.
• Collaborate with chemistry, proteomics, and IPP teams to build and screen E3 ligase focused libraries.
• Develop cell-based and biochemical assays to study E3 ligase biology, target engagement, and molecular glue activity.
• Present scientific findings at conferences and through publications.

Skills

Molecular biology

Biochemistry

Chemical biology

Cell biology

High-throughput screening

CRISPR technologies

Mass spectrometry

Target discovery

Education

PhD in Molecular Biology, Biochemistry, Chemical Biology or related field

Tools

CRISPR technologies

Mass spectrometry

Imaging techniques

Job description

Amgen Inc. (IR) in Thousand Oaks, CA, seeks a Senior Scientist to advance E3 ligase-focused molecular glue screening and drive target discovery within the Induced Proximity Platform (IPP).

You will validate hits, characterize mechanisms, and translate findings into therapeutic opportunities across oncology, inflammation, and rare disease contexts. The role requires a PhD in a relevant field with postdoctoral/industry experience; you will work across biology, chemistry, proteomics, and research