Senior Scientist: Targeted Protein Degradation & Molecular Glue
Initial Therapeutics, Inc.
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Job summary
Amgen in Thousand Oaks is seeking a Senior Scientist to advance targeted protein degradation, focusing on E3 ligases and molecular glue strategies. You will design screening workflows and validate hits, driving discovery of novel targets in oncology and related fields.
Collaborate across chemistry and proteomics teams, develop assays, and present results. A PhD with postdoctoral/industry experience and strong publication record are preferred; competitive benefits and a collaborative culture
Qualifications
- Doctorate degree in a relevant field (e.g., Molecular Biology, Biochemistry) or equivalent.
- Post-doctoral or industry experience preferred.
Responsibilities
- Design and validate molecular glue screening hits and study target biology.
- Evaluate hits in disease-relevant models to identify novel targets.
- Collaborate with chemistry, proteomics, and IPP teams to build E3 ligase-focused libraries.
- Develop cell-based and biochemical assays to study E3 ligase biology and glue activity.
- Contribute to project goals and present results across teams.
- Publish findings at conferences and in journals.
Skills
Education
Tools
Job description
Amgen in Thousand Oaks is seeking a Senior Scientist to advance targeted protein degradation, focusing on E3 ligases and molecular glue strategies. You will design screening workflows and validate hits, driving discovery of novel targets in oncology and related fields.
Collaborate across chemistry and proteomics teams, develop assays, and present results. A PhD with postdoctoral/industry experience and strong publication record are preferred; competitive benefits and a collaborative culture
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