Senior Scientist - Spatial Proteomics & Tissue Imaging

10x Genomics

Pleasanton (CA)

On-site

USD 150,000 - 210,000

Full time

14 days+

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Benefits offered by this job

Equity incentives

Health benefits

Retirement plan

Bonus program

Job summary

10x Genomics is seeking a multidisciplinary scientist to drive research and product development in Spatial Biology, mapping proteins and other biomolecules within intact tissue. A PhD in cell biology, immunology or tumor biology plus experience with high-plex proteomics tissue imaging is essential.

You will collaborate with chemistry, computational biology, software and engineering teams to optimize assays, interpret complex data, and develop reusable protocols for future projects in a

Qualifications

PhD in Molecular/Cell Biology, Immunology, Biochemistry or related field.
5+ years of relevant experience in proteomics, imaging and spatial techniques, in situ hybridization, preferably in the Biotechnology industry.
Hands-on experience with high-plex protein multiplexing technology.
Experience with tissue processing, histology, immunohistochemistry, cryosectioning, immunofluorescence including characterization by surface markers or gene expression.
Extensive experience working with antibodies, including mAb QC, conjugation, functional testing.
Strong analytical background.
Strong organizational skills.
Strong written and oral communication skills.
Strong troubleshooting and problem solving skills.
Ability to work in a fast-paced and quickly changing environment.
Desire to build game-changing technologies and impact the world of life science research.

Responsibilities

Contribute to the optimization of tissue handling and processing protocols for protein staining, including FFPE samples, to improve antigen retention, staining consistency, and compatibility with high-plex imaging workflows.
Design and execute experiments using novel imaging and biochemistry platforms integral to various spatial technology platforms under development at 10x Genomics.
In-depth analysis and reporting of data through documentation and presentations to internal groups.
Work closely with computational biologists and software engineers to interpret data generated by novel optical and biochemical assays.
Develop demonstrated and robust protocols that will be used internally across various teams during product development.

Skills

Cell biology

Immunology

Proteomics

Imaging

Data analysis

Communication

Adaptability

Cross-functional collaboration

Education

PhD in Molecular/Cell Biology, Immunology, Biochemistry or related field

Tools

Python

Omics data analysis software

Image analysis

Job description

You will collaborate with chemistry, computational biology, software and engineering teams to optimize assays, interpret complex data, and develop reusable protocols for future projects in a

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