Senior Scientist, Protein Assay Development – Spatial Biology

10x Genomics; Pleasanton (CA); On-site; USD 150,000 - 210,000; Full time

Benefits offered by this job

Equity incentives

Health benefits

Retirement plan

Bonus program

Job summary

10x Genomics is seeking a multidisciplinary scientist to drive research and product development in Spatial Biology, mapping proteins and other biomolecules within intact tissue. A PhD in cell biology, immunology or tumor biology plus experience with high-plex proteomics tissue imaging is essential.

You will collaborate with chemistry, computational biology, software and engineering teams to optimize assays, interpret complex data, and develop reusable protocols for future projects in a

Qualifications

• PhD in Molecular/Cell Biology, Immunology, Biochemistry or related field.
• 5+ years of relevant experience in proteomics, imaging and spatial techniques, in situ hybridization, preferably in the Biotechnology industry.
• Hands-on experience with high-plex protein multiplexing technology.
• Experience with tissue processing, histology, immunohistochemistry, cryosectioning, immunofluorescence including characterization by surface markers or gene expression.
• Extensive experience working with antibodies, including mAb QC, conjugation, functional testing.
• Strong analytical background.
• Strong organizational skills.
• Strong written and oral communication skills.
• Strong troubleshooting and problem solving skills.
• Ability to work in a fast-paced and quickly changing environment.
• Desire to build game-changing technologies and impact the world of life science research.

Responsibilities

• Contribute to the optimization of tissue handling and processing protocols for protein staining, including FFPE samples, to improve antigen retention, staining consistency, and compatibility with high-plex imaging workflows.
• Design and execute experiments using novel imaging and biochemistry platforms integral to various spatial technology platforms under development at 10x Genomics.
• In-depth analysis and reporting of data through documentation and presentations to internal groups.
• Work closely with computational biologists and software engineers to interpret data generated by novel optical and biochemical assays.
• Develop demonstrated and robust protocols that will be used internally across various teams during product development.

Skills

Cell biology

Immunology

Proteomics

Imaging

Data analysis

Communication

Adaptability

Cross-functional collaboration

Education

PhD in Molecular/Cell Biology, Immunology, Biochemistry or related field

Tools

R

Python

Omics data analysis software

Image analysis

Job description

About the role:

We are looking for an exceptional, multidisciplinary scientist to drive new research and product development efforts in our Spatial Biology department, developing technologies that map protein - and other biomolecules - directly within intact tissue. The ideal candidate will have a proven track-record in cell biology, immunology or tumor biology with extensive experience designing and working with high-plex proteomics tissue imaging assays. This position requires a deep understanding of proteomics and cell biology as you will be applying your skills and knowledge to optimize and evaluate new assays in the area of spatial multiomics in tissues. Additionally, this role will require you to interact closely with colleagues in several departments including chemistry, computational biology, software, engineering and microfluidics. You should have a strong analytical background, be driven by developing revolutionary new products and technologies, and enjoy working in a fast-paced, innovative and truly multi-disciplinary environment. The successful candidate will contribute cell biology, proteomics and immunology expertise and leadership to cross-disciplinary product development teams to ensure project milestones and technological specifications are met.

What you will be doing:

Contribute to the optimization of tissue handling and processing protocols for protein staining, including FFPE samples, to improve antigen retention, staining consistency, and compatibility with high-plex imaging workflows. Design and execute experiments using novel imaging and biochemistry platforms integral to various spatial technology platforms under development at 10x Genomics. This includes in-depth analysis and reporting of your data through documentation and presentations to internal groups. Work closely with computational biologists and software engineers to interpret data generated by novel optical and biochemical assays. Develop demonstrated and robust protocols that will be used internally across various teams during product development.

Minimum Requirements:

• PhD in Molecular/Cell Biology, Immunology, Biochemistry or related field.
• 5+ years of relevant experience in proteomics, imaging and spatial techniques, in situ hybridization, preferably in the Biotechnology industry.
• Hands-on experience with high-plex protein multiplexing technology.
• Experience with tissue processing, histology, immunohistochemistry, cryosectioning, immunofluorescence including characterization by surface markers or gene expression.
• Extensive experience working with antibodies, including mAb QC, conjugation, functional testing.
• Strong analytical background
• Strong organizational skills.
• Strong written and oral communication skills.
• Strong troubleshooting and problem solving skills.
• Ability to work in a fast-paced and quickly changing environment.
• Desire to build game-changing technologies and impact the world of life science research.

Preferred Skills and Experience:

• Pathology experience is a plus.
• Proficiency in R, Python, AI-aided coding or specialized omics data analysis software is a plus.
• Skills in image analysis are a plus

Base Pay and Benefits:

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company's total compensation package.

Company Culture:

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Equal Opportunity Statement:

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.