Senior Scientist, siRNA Screening & Automation Analytics

BioSpace; Worcester (MA); On-site; USD 110,000 - 165,000; Full time

Benefits offered by this job

Paid time off

Medical/Dental/Vision insurance

401(k) plan

Short-term incentive programs

Long-term incentive plan

Job summary

AbbVie is seeking a Senior Scientist in Worcester, MA to support high-throughput siRNA screening with automation-enabled workflows and data analysis. You will collaborate with platform and program teams to accelerate lead discovery and optimization across therapeutic areas.

You will develop scalable screening workflows, mentor junior staff, and contribute to sequencing strategies and data pipelines in a dynamic, collaborative laboratory environment.

Qualifications

• PhD/MS/BS with biotech/pharma experience across discovery and screening.
• Hands-on with automation, high-throughput workflows, and automation scripting.
• Experience with RNA extraction, RT-qPCR, and RNA-seq library prep.
• Familiarity with NGS workflows and data analysis in a team setting.
• Experience with siRNA screening or RNA biology is preferred.
• Strong collaboration and communication across cross-functional teams.

Responsibilities

• Lead high-throughput siRNA screening workflows using automated liquid handling.
• Develop and troubleshoot automation for sample prep incl. RNA extraction and RT-qPCR.
• Design experiments to evaluate siRNA activity and potency.
• Establish data analysis workflows for screening datasets and QC.
• Drive NGS-based strategies for gene expression profiling with automation.
• Collaborate with bioinformatics and platform teams on dataset interpretation.
• Mentor junior scientists and contribute to a collaborative lab environment.
• Document workflows, protocols, and standard operating procedures.

Skills

Lab automation

High-throughput screening

RNA extraction

RT-qPCR

RNA-seq library preparation

NGS data analysis

Automation scripting

Cross-functional teamwork

Education

PhD in Molecular Biology, Genomics, Bioinformatics, or related

MS in Molecular Biology, Genomics, or related

BS in Molecular Biology, Genomics, or related

Tools

NGS platforms

Liquid-handling automation

PCR machines

Sequencers

Job description

AbbVie is seeking a Senior Scientist in Worcester, MA to support high-throughput siRNA screening with automation-enabled workflows and data analysis. You will collaborate with platform and program teams to accelerate lead discovery and optimization across therapeutic areas.

You will develop scalable screening workflows, mentor junior staff, and contribute to sequencing strategies and data pipelines in a dynamic, collaborative laboratory environment.