Senior Scientist, siRNA Screening Automation and Molecular Analytics
BioSpace
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Benefits offered by this job
Job summary
AbbVie is seeking a Senior Scientist in Worcester, MA to support high-throughput siRNA screening with automation-enabled workflows and data analysis. You will collaborate with platform and program teams to accelerate lead discovery and optimization across therapeutic areas.
You will develop scalable screening workflows, mentor junior staff, and contribute to sequencing strategies and data pipelines in a dynamic, collaborative laboratory environment.
Qualifications
- PhD/MS/BS with biotech/pharma experience across discovery and screening.
- Hands-on with automation, high-throughput workflows, and automation scripting.
- Experience with RNA extraction, RT-qPCR, and RNA-seq library prep.
- Familiarity with NGS workflows and data analysis in a team setting.
- Experience with siRNA screening or RNA biology is preferred.
- Strong collaboration and communication across cross-functional teams.
Responsibilities
- Lead high-throughput siRNA screening workflows using automated liquid handling.
- Develop and troubleshoot automation for sample prep incl. RNA extraction and RT-qPCR.
- Design experiments to evaluate siRNA activity and potency.
- Establish data analysis workflows for screening datasets and QC.
- Drive NGS-based strategies for gene expression profiling with automation.
- Collaborate with bioinformatics and platform teams on dataset interpretation.
- Mentor junior scientists and contribute to a collaborative lab environment.
- Document workflows, protocols, and standard operating procedures.
Skills
Education
Tools
Job description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.
AbbVies Biotherapeutic and Genetic Medicine (BGM) department is seeking a highly motivated Senior Scientist to support the development and operation of a high-throughput siRNA screening platform. This role will focus on automation-enabled screening workflowsanddata analysis. The successful candidate will work closely with platform and program teams to build robust, scalable workflows that accelerate siRNA lead discovery and optimization across multiple therapeutic areas.
- Lead execution of high-throughput siRNA screening workflows usingautomatedliquid-handling and other laboratory automation systems.
- Develop, optimize, and troubleshoot automated methods for sample preparation workflows, including RNA extraction, RT-qPCR, and RNA-seq library preparation.
- Design and execute experiments to evaluate siRNA activity, potency, and selectivity using molecular biology assay platforms.
- Establish and maintain data analysis workflows for screening datasets, including assay QC, normalization, hit assessment, and interpretation of experimental results.
- Drive development and implementation of next-generation sequencing (NGS)-based strategies using automation for gene expression profiling.
- Partner with different groups, cross-functional scientists and bioinformatics, to support analysis and interpretation of large screening and sequencing datasets.
- Contribute to the improvement, standardization, and documentation of screening workflows, assay protocols, and automation procedures.
- Identify technical issues proactively and implement solutions to improve assay robustness, throughput, and reproducibility.
- Present results clearly to project teams and platform leadership, and contribute to scientific discussions, experimental planning, and strategy.
- Mentor junior scientists or research associates as needed and contribute to a collaborative, high-performing laboratory environment.
- BS, MS, or PhD in Molecular Biology,Genomics,Bioinformatics, Bioengineering, or a related discipline with typically 0-4+ years (PhD), 8-10+ years (MS), or 10-12+ years (BS) of relevant biotech or pharmaceutical industry experience.
- Strong hands-on experience with laboratory automation,high-throughputscreening workflows,andcoding for automationsystems.
- Deep experience with RNA extractionandRT-qPCR assay development, execution, and troubleshooting.
- Familiarity with NGS workflows for library construction and gene expression profiling, including integration of automation with NGS library preparation or other downstream molecular workflows.
- Experience with siRNA screening, oligonucleotide therapeutics, or RNA biology strongly preferred.
- Familiarity with scripting, data processing tools, or bioinformatics collaboration models.
- Prior experience supporting platform buildout in a matrixed drug discovery environment.
- Strong organizational skills and attention to detail, with ability to manage multiple priorities in a fast-paced environment.
- Excellent communication skills and demonstrated ability to work effectively in cross-functional teams.
Position will be filled at level commensurate with extent of education, experience, and accomplishment - Senior Scientist I or Senior Scientist II
- The compensation range described below is the range of possible base pay compensation that the Companybelieves in good faith it will pay for this role at the time of this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemay ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
- This job may be eligible to participate in our long-term incentive plan.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html
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