Senior Scientist, siRNA Synthesis: Lead & Scale

Allergan; Worcester (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical/dental/vision insurance

401(k)

Paid time off

Short-term incentive programs

Long-term incentive programs

Job summary

AbbVie is seeking a Principal Research Scientist I to join the Biotherapeutic and Genetic Medicine (BGM) siRNA group in Worcester, MA. The role focuses on establishing siRNA synthesis, purification, and analytical capabilities to generate high-quality siRNA materials for genetic medicine studies.

You will mentor junior scientists, collaborate with analytical and conjugation teams, and ensure compliance with quality standards while tracking new RNA-based therapeutics approaches.

Qualifications

• Requires strong knowledge of oligonucleotide chemistry and RNA chemistry.
• Experience collaborating with analytical and conjugation teams.
• Proven ability to independently solve complex technical problems.
• Excellent communication, collaboration, and organizational skills.

Responsibilities

• Lead the siRNA synthesis platform to support various stages of siRNA studies.
• Perform solid-phase oligonucleotide synthesis, deprotection, purification, and desalting of siRNA.
• Troubleshoot synthesis and purification challenges to improve yield, purity, and scalability.
• Work with analytical colleagues to support characterization, data interpretation, and quality assessment of siRNA materials.
• Collaborate with the conjugation team to advance siRNA conjugate development and support platforms and project objectives.
• Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
• Track emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
• Mentor junior scientists and contribute to a collaborative, high-performing team environment.

Skills

Oligonucleotide chemistry

RNA chemistry

Cross-functional collaboration

Data presentation

Troubleshooting

Education

BS/MS/PhD in Chemistry/Biochemistry/Chemical Biology

Tools

Oligonucleotide synthesizers

Liquid chromatography systems

Job description

AbbVie is seeking a Principal Research Scientist I to join the Biotherapeutic and Genetic Medicine (BGM) siRNA group in Worcester, MA. The role focuses on establishing siRNA synthesis, purification, and analytical capabilities to generate high-quality siRNA materials for genetic medicine studies.

You will mentor junior scientists, collaborate with analytical and conjugation teams, and ensure compliance with quality standards while tracking new RNA-based therapeutics approaches.