Senior Scientist, Precision Oncology - Flexible Work

Amgen; Thousand Oaks (CA); On-site; USD 127,000 - 172,000; Full time

Benefits offered by this job

Total Rewards Plan

Annual bonus program

Stock-based incentives

Generous time-off

Job summary

Amgen Inc. is seeking a Senior Scientist in Precision Oncology to shape experimental strategy for emerging oncology programs and translate cancer biology into therapeutic hypotheses.

You will work with cross-functional teams to advance cancer drug discovery, using cutting-edge CRISPR and imaging approaches. The role emphasizes rigorous experimental design, data interpretation, and collaboration across biology, chemistry, and translational sciences to drive program progression and impactful

Qualifications

• Basic Qualifications: Doctorate or Master’s with 2+ years, or Bachelor’s with 4+ years of scientific experience.
• Preferred Qualifications: Ph.D. in Cancer Biology or related discipline with 1–3 years postdoc/industry experience.
• Strong background in cancer cell biology, cell signaling, mechanistic pharmacology, and small-molecule oncology drug discovery with publications or patents.
• Subject-matter expertise in advanced CRISPR technologies and genome engineering.

Responsibilities

• Design and execute studies to validate oncology targets and define mechanisms of action.
• Apply CRISPR genome-editing to establish target function and dependencies.
• Evaluate emerging technologies and AI tools to accelerate oncology discovery.
• Establish quantitative assays to investigate target engagement, pathways, and protein function.
• Analyze complex data and communicate insights to multidisciplinary teams.
• Collaborate with researchers across the Oncology group to advance drug discovery.

Skills

Cancer biology

Cell biology

Quantitative design

Data analysis

Education

Ph.D. in Cancer Biology or related

Tools

CRISPR technologies

High-content imaging

Live-cell imaging

Image-analysis workflows

Job description

Amgen Inc. is seeking a Senior Scientist in Precision Oncology to shape experimental strategy for emerging oncology programs and translate cancer biology into therapeutic hypotheses.

You will work with cross-functional teams to advance cancer drug discovery, using cutting-edge CRISPR and imaging approaches. The role emphasizes rigorous experimental design, data interpretation, and collaboration across biology, chemistry, and translational sciences to drive program progression and impactful