Senior Scientist, Structural Biology — Flexible Work

Amgen

South San Francisco (CA)

On-site

USD 140,000 - 210,000

Full time

14 days+
Application generator

Get a reply from this employer — a resume and cover letter tailored to exactly what they’re hiring for.

Get past ATS filters

Benefits offered by this job

Total Rewards Plan
Flexible work models
Stock-based incentives

Job summary

Amgen in South San Francisco is seeking a Scientist/Senior Scientist in Structural Biology to advance cryo-EM and integrative structure-based drug discovery across therapeutic areas, enabling therapeutic program decisions.

This role blends hands-on experimentation with technology development, mentoring, and cross-functional collaboration to deliver high-impact insights, publish findings, and help build scalable workflows that improve throughput and data quality.

Qualifications

  • Doctorate in Structural Biology, Biochemistry, Biophysics, or related field.
  • Alternatives include PharmD or MD with relevant post-doc experience.
  • Master’s degree with 3 years of Structural Biology experience or Bachelor’s with 5 years.

Responsibilities

  • Define structural biology strategies and experimental plans with discovery teams.
  • Perform cryo-EM sample prep, data collection, and model building.
  • Deliver high-quality structural insights to inform design decisions.
  • Develop scalable CryoEM workflows to improve throughput.
  • Collaborate across Structural Biology, Protein Sciences, Therapeutic Discovery, and Computational Biology teams.
  • Evaluate and implement emerging technologies to improve data collection and analysis.

Skills

CryoEM
Structural biology
X-ray crystallography
Data analysis
Python scripting

Education

PhD in Structural Biology
MD
PharmD
Master's degree in related field
Bachelor's degree in related field

Tools

Glacios
Titan Krios
EPU
CryoEM automation software

Job description

Amgen in South San Francisco is seeking a Scientist/Senior Scientist in Structural Biology to advance cryo-EM and integrative structure-based drug discovery across therapeutic areas, enabling therapeutic program decisions.

This role blends hands-on experimentation with technology development, mentoring, and cross-functional collaboration to deliver high-impact insights, publish findings, and help build scalable workflows that improve throughput and data quality.

Get your free, confidential resume review.
or drag and drop your file here.
Similar jobs

Similar jobs worth comparing

Senior Scientist, Structural Biology & CryoEM — Flexible Work
Senior Scientist, Structural Biology & CryoEM — Flexible Work

Amgen SA • South San Francisco (CA)

On-site
USD 150,000 - 200,000
Retirement and Savings Plan
Medical, dental and vision coverage
Life and disability insurance
+5
Senior Scientist, Structural Biology - Flexible CryoEM
Senior Scientist, Structural Biology - Flexible CryoEM

BioSpace • South San Francisco (CA)

On-site
USD 150,000 - 210,000
Retirement plan and company match
Medical, dental, vision coverage
Life and disability insurance
+2
Senior Scientist, CryoEM & Structural Biology Innovator
Senior Scientist, CryoEM & Structural Biology Innovator

Biopharma Careers • South San Francisco (CA)

On-site
USD 143,000 - 193,000
Retirement and savings plan
Medical, dental and vision coverage
Discretionary annual bonus
+2
Scientist / Senior Scientist, Structural Biology
Scientist / Senior Scientist, Structural Biology

Amgen SA • South San Francisco (CA)

On-site
USD 150,000 - 200,000
Retirement and Savings Plan
Medical, dental and vision coverage
Life and disability insurance
+5
Senior Scientist Protein Biochemistry & Structural Biology
Senior Scientist Protein Biochemistry & Structural Biology

Initial Therapeutics, Inc. • Thousand Oaks (CA)

On-site
USD 120,000 - 180,000
Scientist / Senior Scientist, Structural Biology
Scientist / Senior Scientist, Structural Biology

BioSpace • South San Francisco (CA)

On-site
USD 150,000 - 210,000
Retirement plan and company match
Medical, dental, vision coverage
Life and disability insurance
+2
Scientist / Senior Scientist, Structural Biology
Scientist / Senior Scientist, Structural Biology

Biopharma Careers • South San Francisco (CA)

On-site
USD 143,000 - 193,000
Retirement and savings plan
Medical, dental and vision coverage
Discretionary annual bonus
+2
Scientist / Senior Scientist, Structural Biology
Scientist / Senior Scientist, Structural Biology

Amgen • South San Francisco (CA)

On-site
USD 140,000 - 210,000
Total Rewards Plan
Flexible work models
Stock-based incentives
Principal Scientist: Structural Dynamics for Drug Discovery
Principal Scientist: Structural Dynamics for Drug Discovery

F. Hoffmann-La Roche AG • South San Francisco (CA)

On-site
USD 151,000 - 280,000
Relocation assistance
Discretionary annual bonus
Principal Scientist, Structural Biology — Drug Discovery
Principal Scientist, Structural Biology — Drug Discovery

Genentech • San Francisco (CA)

On-site
USD 151,000 - 280,000
Relocation assistance
Relocation assistance