Senior Scientist, PK/PD Modeling & Drug Metabolism

Gilead Sciences Inc.; Foster City (CA); On-site; USD 169,000 - 219,000; Full time

Benefits offered by this job

Medical benefits

Dental benefits

Vision benefits

Stock options

Paid time off

Bonus potential

Job summary

Gilead Sciences Inc. in Foster City, CA is seeking a Senior Scientist, Drug Metabolism to serve as an expert in PK/PD modeling for small molecules and biologics.

You will provide strategic scientific input to discovery and development teams, applying advanced quantitative approaches to characterize ADME properties and support dose selection. The role emphasizes AI-enabled modeling, complex PK/PD workflows, and collaboration with interdisciplinary teams to translate findings into actionable

Qualifications

• Advanced PK/PD modeling experience.
• Experience in nonclinical PK and toxicology studies.
• Ability to translate concepts into mathematical models.

Responsibilities

• Provide advanced PK/PD modeling expertise on project teams across discovery and development stages.
• Drive quantitative DMPK strategy and integrate modeling into decision-making.
• Design, implement, and validate complex PK/PD and mechanistic models for dose selection and translational predictions.
• Develop and refine modeling workflows for nonclinical study design with AI-based enhancements.
• Collaborate with project teams and CROs to ensure timely regulatory submissions.
• Participate in business development and licensing evaluations.

Skills

PK/PD modeling

AI workflows

Multi-compartmental modeling

Cross-functional collaboration

Education

Master's degree

PhD

Tools

Phoenix/WinNonlin

MATLAB/SimBiology

GastroPlus

SimBiology

R

Job description

Gilead Sciences Inc. in Foster City, CA is seeking a Senior Scientist, Drug Metabolism to serve as an expert in PK/PD modeling for small molecules and biologics.

You will provide strategic scientific input to discovery and development teams, applying advanced quantitative approaches to characterize ADME properties and support dose selection. The role emphasizes AI-enabled modeling, complex PK/PD workflows, and collaboration with interdisciplinary teams to translate findings into actionable