Scientist, Drug Metabolism & PK/PD Modeling

Gilead Sciences Inc.; Foster City (CA); On-site; USD 147,000 - 190,000; Full time

Benefits offered by this job

Discretionary annual bonus

Stock-based long-term incentives

Paid time off

Benefits package (medical/dental/vison

Job summary

Gilead Sciences Inc. is seeking a Scientist, Drug Metabolism at its Foster City site to support PK/PD modeling across discovery and development, with emphasis on large-molecule therapeutics such as biologics and multispecifics. The role focuses on mechanistic modeling to inform study design, human PK and dose predictions, and program decisions.

Applicants should have a Ph.D. with post-graduate PK/PD experience or a Master’s with substantial experience, and be proficient in Phoenix/WinNonlin,

Qualifications

• Ph.D. with 0+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or related field, focus on quantitative PK/PD modeling.
• Masters with 4+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or related field, focus on quantitative PK/PD modeling.
• Strong foundation in PK/PD principles and mathematical modeling, with knowledge of large-molecule disposition, TMDD, target engagement, translational PK.
• Experience with mechanistic PK/PD and multi-compartmental modeling; proficiency in software tools listed in the qualifications.

Responsibilities

• Provide PK and PK/PD modeling support across discovery and development for large molecules, including biologics and multispecifics.
• Contribute to quantitative DMPK strategies with interdisciplinary project teams.
• Develop mechanistic PK/PD models to address translational questions and dose predictions.
• Develop modeling/simulation workflows for nonclinical study design and data interpretation, incorporating AI where appropriate.
• Analyze and communicate modeling results to project teams and management.
• Collaborate with CROs and management to ensure timely delivery of analyses for regulatory submissions.
• Support business development and licensing evaluations with quantitative modeling insights.

Skills

PK/PD modeling

Mechanistic PK/PD

Multi-compartmental modeling

Large-molecule PK/PD

TMDD/Target engagement

AI in modeling workflows

Communication of results

Education

Ph.D. with 0+ years

Masters with 4+ years

Tools

Phoenix/WinNonlin

MATLAB/SimBiology

R

GastroPlus

Job description

Gilead Sciences Inc. is seeking a Scientist, Drug Metabolism at its Foster City site to support PK/PD modeling across discovery and development, with emphasis on large-molecule therapeutics such as biologics and multispecifics. The role focuses on mechanistic modeling to inform study design, human PK and dose predictions, and program decisions.

Applicants should have a Ph.D. with post-graduate PK/PD experience or a Master’s with substantial experience, and be proficient in Phoenix/WinNonlin,