Scientist, Drug Metabolism

Gilead Sciences Inc.; Foster City (CA); Presencial; USD 147.000 - 190.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Discretionary annual bonus

Stock-based long-term incentives

Paid time off

Benefits package (medical/dental/vison

Descripción de la vacante

Gilead Sciences Inc. is seeking a Scientist, Drug Metabolism at its Foster City site to support PK/PD modeling across discovery and development, with emphasis on large-molecule therapeutics such as biologics and multispecifics. The role focuses on mechanistic modeling to inform study design, human PK and dose predictions, and program decisions.

Applicants should have a Ph.D. with post-graduate PK/PD experience or a Master’s with substantial experience, and be proficient in Phoenix/WinNonlin,

Formación

• Ph.D. with 0+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or related field, focus on quantitative PK/PD modeling.
• Masters with 4+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or related field, focus on quantitative PK/PD modeling.
• Strong foundation in PK/PD principles and mathematical modeling, with knowledge of large-molecule disposition, TMDD, target engagement, translational PK.
• Experience with mechanistic PK/PD and multi-compartmental modeling; proficiency in software tools listed in the qualifications.

Responsabilidades

• Provide PK and PK/PD modeling support across discovery and development for large molecules, including biologics and multispecifics.
• Contribute to quantitative DMPK strategies with interdisciplinary project teams.
• Develop mechanistic PK/PD models to address translational questions and dose predictions.
• Develop modeling/simulation workflows for nonclinical study design and data interpretation, incorporating AI where appropriate.
• Analyze and communicate modeling results to project teams and management.
• Collaborate with CROs and management to ensure timely delivery of analyses for regulatory submissions.
• Support business development and licensing evaluations with quantitative modeling insights.

Conocimientos

PK/PD modeling

Mechanistic PK/PD

Multi-compartmental modeling

Large-molecule PK/PD

TMDD/Target engagement

AI in modeling workflows

Communication of results

Educación

Ph.D. with 0+ years

Masters with 4+ years

Herramientas

Phoenix/WinNonlin

MATLAB/SimBiology

R

GastroPlus

Descripción del empleo

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers.

We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come.

As a Scientist, Drug Metabolism at Gilead you will support PK and PK/PD modeling across discovery and development, with an emphasis on large-molecule therapeutics, including biologics, ADCs, and multispecific/T-cell engagers. The role will apply mechanistic and translational modeling to support study design, human PK and dose predictions, and program decision-making.

This is a site-based position at our Foster City campus.

Essential Duties and Job Responsibilities

• Provide PK and PK/PD modeling support across discovery and development, with particular emphasis on large molecules, including biologics, ADCs, and multispecific/T-cell engager therapeutics . Contribute to the design and interpretation of nonclinical PK, toxicology, and pharmacology studies.
• Contribute to quantitative DMPK strategies by working with interdisciplinary project teams to apply modeling approaches to program questions and decision-making.
• Develop and apply mechanistic PK/PD models to address translational questions, support dose selection, and predict first-in-human exposures, including approaches relevant to large-molecule PK, TMDD, target engagement, and nonlinear disposition .
• Develop and apply modeling and simulation workflows to support nonclinical study design and data interpretation, incorporating AI-based approaches where appropriate.
• Analyze and communicate modeling results and recommendations to project teams, collaborators, and management.
• Work with project teams, line management, and CROs to support high-quality and timely delivery of analyses and documents for regulatory submissions.
• Contribute quantitative modeling expertise to business development and licensing evaluations.

Requirements:

• Ph.D. with 0+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or a related field, with a focus on quantitative PK/PD modeling OR
• Masters with 4+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or a related field, with a focus on quantitative PK/PD modeling
• Strong foundation in PK/PD principles and mathematical modeling, with knowledge of large-molecule disposition, TMDD, target engagement, and translational PK .
• Experience with mechanistic PK/PD and multi-compartmental modeling and proficiency in Phoenix/WinNonlin, MATLAB/SimBiology, R, GastroPlus, or equivalent tools.
• Ability to design and interpret modeling workflows, draw conclusions from quantitative analyses, and clearly communicate results to diverse audiences.
• Experience applying AI to model building and/or automation of modeling workflows.
• Intellectual curiosity and interest in advances in biologics DMPK and quantitative modeling , with evidence of scientific contributions through publications, presentations, and/or professional activities

Preferred:

• Degree concentration in engineering or pharmacology
• Experience with large-molecule therapeutics, including biologics, ADCs, multispecific antibodies/T-cell engagers, or other protein therapeutics

People Leader Accountabilities:

• Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams.
• Develop Talent - understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop and realize their purpose.
• Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.

The salary range for this position is: $146,540.00 - $189,640.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary.

This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package.

Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

For jobs in the United States:

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex , age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact [e-mail] for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.

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YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law.

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.