Senior Scientist or Associate Principal Scientist, LCMS Platform

CRYSTAL PHARMATECH INC; Pleasanton (CA); On-site; USD 120,000 - 165,000; Full time

Job summary

Crystal Bio Solutions in Pleasanton, CA, is seeking a Senior Scientist or Associate Principal Scientist to lead LCMS bioanalysis for PK and biomarkers, supporting pre-clinical and clinical projects. The role requires expertise in LCMS method development/validation, data interpretation, and mentoring junior staff, with a focus on quality, compliance, and client collaboration.

Strong candidates will have a PhD or MS in analytical chemistry or related fields and hands-on experience with GLP/GCLP

Qualifications

• Ph.D., M.Sc., M.A., or B.A. in analytical chemistry, biochemistry or related fields with CRO/pharma/biotech experience.
• Hands-on LCMS method development and troubleshooting for small molecules and biologics (ADC, mAB, protein, peptide, oligonucleotide).
• GLP/GCLP LCMS method development/validation experience preferred; familiarity with LIMS and QMS systems.

Responsibilities

• Propose assay design and develop/validate LCMS bioanalytical methods for PK and biomarker measurements.
• Serve as LCMS SME; present data internally/externally as needed.
• Oversee laboratory operations, mentor junior staff, and drive operational excellence.
• Ensure compliance with EHS and GLP/GCP/GDP standards.
• Perform other related duties as assigned.

Skills

LCMS method development

Analytical chemistry

Biochemistry

Team collaboration

Scientific writing

Mentoring

Education

Ph.D. in Analytical Chemistry

M.Sc. in Analytical Chemistry or Biochemistry

Bachelor's degree

Tools

LIMS

QMS

Job description

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Senior Scientist or Associate Principal Scientist, LCMS Platform

FullTime Pleasanton, CA, US

30+ days ago Requisition ID: 1001

Salary Range: $120,000.00 To $165,000.00 Annually

Position Summary:

Crystal Bio Solutions is a CRO providing global-standard services in GLP/GCLP bioanalysis and biomarker. Our clients include multinational pharmaceutical companies and biotech companies.

The Bioanalysis & Biomarkers Department specializes in Method Development, Method Validation, GLP/GCLP Bioanalysis for PK, and biomarkers. The team has successfully supported non-GLP, GLP (non-clinical) and GCLP (clinical) projects. The role is responsible for providing bioanalytical support for both pre-clinical and clinical projects and partnering with our clients for project success.

Key Responsibilities:

• Independently propose assay design and/or strategy, develop, validate, conduct, and troubleshoot LCMS-based bioanalytical methods for the quantification of small molecule (and its metabolites) and biologics (e.g. ADC, mAB, protein, peptide, oligonucleotide etc) in support of PK, and Biomarker measurement
• Serve as Subject Matter Expert (SME) for LCMS platform.
• Present and interpret data internally and/or externally as needed.
• Provide oversight of the laboratory, mentor junior staff, and collaborate to keep improving operational excellence.
• Understand and adhere to corporate standards regarding code of conduct, Environment Health & Safety (EHS), and GLP/GCP/GDP compliance.
• Perform other related duties as assigned.

Qualifications & Educational Requirements:

• Ph.D., M.Sc., M.A., B.A., in Analytical Chemistry, Biochemistryor other related scientific fields required, including a minimum of 0 + (Ph.D.), 9 + (Master’s) or 12 + (Bachelor’s) years of CRO/Pharma/Biotech experience.
• Hands-on experience, strong expertise in LCMS method development and troubleshooting for small molecules and biologics (e.g. ADC, mAB, protein, peptide, oligonucleotide etc) are required.
• Established record of independent achievement of objectives and timelines while maintaining high work quality.
• Effective in team environments co-workers, managers, and clients.
• Must be goal-oriented, quality-conscientious, compliance-ensured, and client-focused.
• Effective writing and communication skills, preferred.
• Experience in GLP/GCLP LCMS method development and validation for PK and/or biomarker analysis is preferred .
• Functional experience utilizing LIMS and QMS systems for GLP/GCLP bioanalysis is preferred
• Familiarity with additional bioanalytical platforms (e.g. LBA, PCR, Flow Cytometry) is a plus.
• Supervisory experience in both project and talent (people) management is a plus.
• The salary range represents the anticipated base pay for this position. Actual compensation may vary based on factors including, but not limited to, skills, qualifications, experience, education, and location.
• As part of our recruitment process, we may use technology-assisted tools to support application review and improve efficiency. All hiring decisions are made by our team.