Senior Scientist: Molecular Eng & Tissue Optimization

Convergent Research; Alameda (CA); Hybrid; USD 100,000 - 191,000; Full time

Benefits offered by this job

Bonus up to 20% of base salary

401k match up to 6% of base salary

Job summary

E11 Bio in Alameda, CA is seeking a Scientist to join a neuroscience moonshot project dedicated to scalable mammalian brain mapping.

You will develop and deploy assays, establish quantitative metrics for tissue quality, and collaborate with in vivo teams to design experiments and optimize SOPs; contribute to data-analysis pipelines and binder design in hydrogels to improve readouts of synapses and cell types.

Responsibilities

• Develop and deploy an assay to systematically evaluate and improve the fixation quality and preservation of brain tissue
• Establish and integrate quantitative metrics of molecular readout e.g. protein retention, antigenicity, and labeling quality across tissue preparation conditions
• Work closely with in vivo research technicians to design experiments, evaluate results, and optimize SOPs
• Drive the development of data-analysis pipelines to routinely generate key performance indicators of sample tissue quality
• Generate an in-house pipeline for binder design/discovery, validation, and optimization of epitope-binder pairs in hydrogels to improve the readout of epitope barcode bits and relevant native synaptic proteins
• Develop novel highly multiplexed protein readout strategies for protein barcodes and molecular annotation of synapses and cell types

Job description

E11 Bio in Alameda, CA is seeking a Scientist to join a neuroscience moonshot project dedicated to scalable mammalian brain mapping.

You will develop and deploy assays, establish quantitative metrics for tissue quality, and collaborate with in vivo teams to design experiments and optimize SOPs; contribute to data-analysis pipelines and binder design in hydrogels to improve readouts of synapses and cell types.