Senior Scientist, Molecular Engineering & Brain Readout

Ring Inc; Alameda (CA); On-site; USD 100,000 - 240,000; Full time

Job summary

E11 Bio in Alameda, California is seeking a Scientist to help advance brain mapping by developing and deploying assays to assess fixation quality and tissue preservation. You will establish quantitative metrics for protein retention, antigenicity, and labeling across tissue prep conditions.

You will collaborate with in vivo technicians to design experiments, evaluate results, and optimize SOPs, while driving data-analysis pipelines for tissue quality indicators and epitope-binder readouts in

Responsibilities

• Develop and deploy an assay to systematically evaluate and improve the fixation quality and preservation of brain tissue
• Establish and integrate quantitative metrics of molecular readout e.g. protein retention, antigenicity, and labeling quality across tissue preparation conditions
• Work closely with in vivo research technicians to design experiments, evaluate results, and optimize SOPs
• Drive the development of data-analysis pipelines to routinely generate key performance indicators of sample tissue quality
• Generate an in-house pipeline for binder design/discovery, validation, and optimization of epitope-binder pairs in hydrogels to improve the readout of epitope barcode bits and relevant native synaptic proteins
• Develop novel highly multiplexed protein readout strategies for protein barcodes and molecular annotation of synapses and cell types

Job description

E11 Bio in Alameda, California is seeking a Scientist to help advance brain mapping by developing and deploying assays to assess fixation quality and tissue preservation. You will establish quantitative metrics for protein retention, antigenicity, and labeling across tissue prep conditions.

You will collaborate with in vivo technicians to design experiments, evaluate results, and optimize SOPs, while driving data-analysis pipelines for tissue quality indicators and epitope-binder readouts in