Senior Scientist, Induced Proximity & Target Validation

Nurix; Brisbane (CA); On-site; USD 162,000 - 209,000; Full time

Job summary

Nurix Therapeutics in Brisbane, CA is seeking a Senior/Principal Scientist for Induced Proximity to advance non-degradative strategies. You will design and run assays to validate targets, characterize mechanisms, and guide go/no-go decisions, collaborating across chemistry, biology, and biochemistry teams.

You will contribute to target engagement, mechanistic pharmacology, and integration of new modalities into the platform roadmap, with opportunities for leadership exposure.

Qualifications

• Ph.D. in biology, biochemistry, molecular biology, or a related field.
• 5+ years of industry drug discovery with induced proximity modality work.
• Hands-on biophysical and biochemical assay development for ternary complex formation.
• Cell-based mechanistic pharmacology with diverse readouts.
• CRISPR and RNAi based target validation and genomics.
• Engages in data analysis, QC, and disciplined ELN documentation.
• Proven cross-functional collaboration and senior-level communication.

Responsibilities

• Design, execute, and troubleshoot bench experiments in biochemical, biophysical, and cell-based assays.
• Identify, validate, and prioritize targets for induced proximity approaches.
• Integrate new modalities into strategic roadmaps and project plans.
• Collaborate with computational biology to model ternary complex formation.
• Present data and recommendations to teams and leadership.
• Ensure programs meet milestones from discovery to IND-enabling work.

Skills

Induced proximity experience

Biophysical assay development

Cell-based pharmacology

Cross-functional collaboration

Data analysis & QC

Scientific communication

Education

Ph.D. in biology/biochemistry/molecular biology

Post-graduate industry research experience (4+ yrs)

Tools

TR-FRET/HTRF

NanoBRET

AlphaLISA

SPR

ITC

MST

DSF

Job description

Nurix Therapeutics in Brisbane, CA is seeking a Senior/Principal Scientist for Induced Proximity to advance non-degradative strategies. You will design and run assays to validate targets, characterize mechanisms, and guide go/no-go decisions, collaborating across chemistry, biology, and biochemistry teams.

You will contribute to target engagement, mechanistic pharmacology, and integration of new modalities into the platform roadmap, with opportunities for leadership exposure.