Senior Scientist, Induced Proximity & Drug Discovery

Nurix Therapeutics

Brisbane (CA)

On-site

USD 162,000 - 209,000

Full time

5 days ago

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Job summary

Nurix Therapeutics, Inc. is seeking a scientist to support the non-degradative induced proximity research strategy.

This role designs and runs biochemical, biophysical, and cell-based assays to validate targets and inform go/no-go decisions in a fast-evolving drug discovery platform. You will work with chemistry, biology, and biochemistry teams to translate priorities into experiments, generate data, and contribute ideas on novel modalities and technologies, with opportunities for leadership in

Qualifications

Ph.D. in biology, biochemistry, molecular biology, or a related field.
5+ years of industry drug discovery experience with induced proximity modalities.
Hands-on biophysical and biochemical assay development to quantify ternary complex formation and cooperativity (e.g. TR-FRET/HTRF, NanoBRET, AlphaLISA, SPR, ITC, MST, DSF).
Experience in biochemical assay development of the relevant proximity-induced reaction (e.g. ubiquitination, phosphorylation, acetylation).
Cell-based mechanistic pharmacology: Western blot, HiBiT/NanoLuc kinetics, flow cytometry, reporter assays, & dose–response studies.
CRISPR knockout/knock-in, CRISPRa/CRISPRi, and siRNA for target validation.
Target engagement and protein-stability methods: CETSA, NanoBRET, co-IP/pulldown, cycloheximide-chase.
Deep mechanistic understanding of ternary complex biology and ubiquitin–proteasome/autophagy–lysosomal pathways.
Rigorous experimental design and quantitative data analysis; QC (Z′, dynamic range); graphing in GraphPad Prism; ELN documentation.
Cross-functional collaboration with biology, chemistry, and DMPK; strong scientific communication with leadership.

Responsibilities

Design, execute, and troubleshoot bench experiments to interrogate induced proximity mechanisms.
Contribute to target validation and prioritization for induced proximity approaches.
Evaluate and integrate new modalities into the strategic roadmap; partner with computational/structural biology for ternary complex design.
Present data, interpretations, and recommendations to project teams and senior leadership.
Ensure programs meet milestones from discovery through IND-enabling work.
Stay current on the competitive and scientific landscape; contribute to external publications/presentations as needed.