Senior Scientist, Immuno-Oncology Bioassays (Onsite)

Systimmune; Bothell (WA); On-site; USD 90,000 - 140,000; Full time

Job summary

SystImmune, a leading clinical-stage biopharmaceutical company in Bothell, WA, seeks a Senior Scientist for the Immuno-Oncology Bioassay Team onsite. You will design, develop, and automate high-throughput bioanalytical assays to support discovery and preclinical characterization of IO antibody therapeutics, including bispecifics, multi-specifics, and ADCs.

This hands-on role requires daily bench work in a BSL-2 lab and collaboration with discovery, translational science, and IND-enabling groups.

Qualifications

• PhD in immunology, cancer biology or related field with 2-5+ years of relevant academic and/or pharmaceutical or biotech experience.
• Hands-on experience in the discovery and development of protein therapeutics, with a focus on functional bioassays and mammalian cell culture.
• Background in human immune cell biology, immune checkpoint signaling, or T-cell/B-cell receptor signaling research.
• Direct experience developing and running bioassays for bispecific antibodies, multi-specific formats, or ADCs is strongly preferred.
• Proficiency in high-dimensional data analysis and visualization (e.g., flow cytometry, multiplex assays) using tools such as R or Python.
• Experience in assay automation is a plus.
• Excellent time management, organizational skills, and written/oral communication abilities.
• Possess the right attitude (agile, curious, positive, open-minded, “can-do” mindset)

Responsibilities

• Design, establish, and execute mechanism-driven in vitro preclinical bioassays (including ex vivo and human translational systems) to identify, characterize, and advance novel immuno-oncology antibody therapeutic
• Perform routine assay runs, troubleshoot and resolve assay performance issues, and maintain assay documentation and SOPs.
• Oversee sample management, method quality control, and inter-site harmonization through systems like LIMS.
• Prepare written reports, assay summaries, and oral presentations for internal review, cross-functional meetings, and support regulatory submissions.
• Mentor junior team members and contribute to assay platform standardization, automation across the expanded Bioassay Team.
• Support IND-enabling studies, GLP transitions, and regulatory audits as assigned.
• Other duties as assigned

Skills

Bioassay development

Mammalian cell culture

Flow cytometry analysis

R/Python data analysis

Education

PhD in immunology or cancer biology

Tools

LIMS

Automation platforms

Job description

SystImmune, a leading clinical-stage biopharmaceutical company in Bothell, WA, seeks a Senior Scientist for the Immuno-Oncology Bioassay Team onsite. You will design, develop, and automate high-throughput bioanalytical assays to support discovery and preclinical characterization of IO antibody therapeutics, including bispecifics, multi-specifics, and ADCs.

This hands-on role requires daily bench work in a BSL-2 lab and collaboration with discovery, translational science, and IND-enabling groups.