Senior Scientist, Bioassay Team

Systimmune; Bothell (WA); On-site; USD 90,000 - 140,000; Full time

Job summary

SystImmune, a leading clinical-stage biopharmaceutical company in Bothell, WA, seeks a Senior Scientist for the Immuno-Oncology Bioassay Team onsite. You will design, develop, and automate high-throughput bioanalytical assays to support discovery and preclinical characterization of IO antibody therapeutics, including bispecifics, multi-specifics, and ADCs.

This hands-on role requires daily bench work in a BSL-2 lab and collaboration with discovery, translational science, and IND-enabling groups.

Qualifications

• PhD in immunology, cancer biology or related field with 2-5+ years of relevant academic and/or pharmaceutical or biotech experience.
• Hands-on experience in the discovery and development of protein therapeutics, with a focus on functional bioassays and mammalian cell culture.
• Background in human immune cell biology, immune checkpoint signaling, or T-cell/B-cell receptor signaling research.
• Direct experience developing and running bioassays for bispecific antibodies, multi-specific formats, or ADCs is strongly preferred.
• Proficiency in high-dimensional data analysis and visualization (e.g., flow cytometry, multiplex assays) using tools such as R or Python.
• Experience in assay automation is a plus.
• Excellent time management, organizational skills, and written/oral communication abilities.
• Possess the right attitude (agile, curious, positive, open-minded, “can-do” mindset)

Responsibilities

• Design, establish, and execute mechanism-driven in vitro preclinical bioassays (including ex vivo and human translational systems) to identify, characterize, and advance novel immuno-oncology antibody therapeutic
• Perform routine assay runs, troubleshoot and resolve assay performance issues, and maintain assay documentation and SOPs.
• Oversee sample management, method quality control, and inter-site harmonization through systems like LIMS.
• Prepare written reports, assay summaries, and oral presentations for internal review, cross-functional meetings, and support regulatory submissions.
• Mentor junior team members and contribute to assay platform standardization, automation across the expanded Bioassay Team.
• Support IND-enabling studies, GLP transitions, and regulatory audits as assigned.
• Other duties as assigned

Skills

Bioassay development

Mammalian cell culture

Flow cytometry analysis

R/Python data analysis

Education

PhD in immunology or cancer biology

Tools

LIMS

Automation platforms

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

This is a hands-on laboratory role within the Immuno-Oncology Bioassay Team. The Senior Scientist will design, develop, execute, and automate high-throughput bioanalytical and functional assays to support the discovery and preclinical characterization of immuno-oncology antibody therapeutics, including bispecifics, multi-specific antibodies, and ADCs. This position requires daily bench work in a BSL-2 environment and close collaboration with cross-functional teams across discovery, translational science, and IND-enabling studies.

This position is full-time onsite position in Bothell, WA.

Responsibilities

• Design, establish, and execute mechanism-driven in vitro preclinical bioassays (including ex vivo and human translational systems) to identify, characterize, and advance novel immuno-oncology antibody therapeutic
• Perform routine assay runs, troubleshoot and resolve assay performance issues, and maintain assay documentation and SOPs.
• Oversee sample management, method quality control, and inter-site harmonization through systems like LIMS.
• Prepare written reports, assay summaries, and oral presentations for internal review, cross-functional meetings, and support regulatory submissions.
• Mentor junior team members and contribute to assay platform standardization, automation across the expanded Bioassay Team.
• Support IND-enabling studies, GLP transitions, and regulatory audits as assigned.
• Other duties as assigned

Qualifications

• PhD in immunology, cancer biology or related field with 2-5+ years of relevant academic and/or pharmaceutical or biotech experience.
• Hands-on experience in the discovery and development of protein therapeutics, with a focus on functional bioassays and mammalian cell culture.
• Background in human immune cell biology, immune checkpoint signaling, or T-cell/B-cell receptor signaling research.
• Direct experience developing and running bioassays for bispecific antibodies, multi-specific formats, or ADCs is strongly preferred.
• Proficiency in high-dimensional data analysis and visualization (e.g., flow cytometry, multiplex assays) using tools such as R or Python.
• Experience in assay automation is a plus.
• Excellent time management, organizational skills, and written/oral communication abilities.
• Possess the right attitude (agile, curious, positive, open-minded, “can-do” mindset), and have the ability and strong desire to “make things happen”

Work Environment

• Bench top work in a BSL-2 laboratory environment, including potential exposure to biohazards
• Adherence to Health and Safety standards when working with temperature-controlled systems, including liquid and vapor phase liquid nitrogen

Physical Demands

• Occasional lifting to 30 pounds
• Requires repetitive multi-channel pipetting, single channel pipetting, and computer data entry
• Fine motor movements in fingers/hands to operate computers and other office and lab equipment, repetitive motion with lab equipment
• Stooping, bending, crouching, reaching, or climbing ladders

Position Type/Expected Hours of Work

• May need to work outside of standard working hours at times
• This role is currently working onsite and is expected to work onsite for working hours, with flexibility to work start time.

Travel

• Attendance and participation in national and international conferences encouraged

Compensation and Benefits

The expected base salary range for this position is $90,000 - $140,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.

While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.