Senior Associate Scientist – Immuno-oncology

Integrated Resources, Inc ( IRI ); San Mateo (CA); On-site; USD 68,880 - 79,280; Full time

Job summary

A leading biopharmaceutical company located in Foster City, CA is seeking a Senior Associate Scientist to contribute to immuno-oncology research. The position requires expertise in immune cell assays, including isolation and gene editing, and offers opportunities for career development in a collaborative and innovative environment focused on addressing unmet medical needs in cancer treatment. This role is on-site five days a week, ensuring close interaction with interdisciplinary teams.

Qualifications

• Master's or Bachelor's degree with relevant experience in immunology.
• Direct experience in research drug discovery and target identification in oncology is desirable.
• Solid understanding of immunology concepts including innate and adaptive immunity.
• Proficiency in primary T cell-based functional assays.

Responsibilities

• Execute in vitro and in vivo immunological assays.
• Evaluate new technologies and develop new assays for discovery activities.
• Manage multiple projects and work cross-functionally.

Skills

Human and mouse primary immune cell isolation and functional assays (T cells in particular)

Immune cell gene editing (e.g., CRISPR-Cas9, lentivirus, transposase-based systems)

Multi-color flow cytometry, including panel design, sample processing, and data acquisition

Education

Master's degree with 5+ years of experience or Bachelor's degree with 8+ years of experience in immunology or related fields

Tools

CRISPR technology

Flow cytometry

ELISA/Luminex/MSD

Job description

Job title: Senior associate Scientist - Biology – Immuno-oncology

Location: Foster city, CA - On-site (5 days a week)

Pay rate range: $50.00 - $57.55/hour on W2.

Job Summary:

Client (Foster City, CA) is seeking a talented and highly motivated Senior associate Scientist/Scientist to join our Immuno-oncology group. Our collaborative and interdisciplinary research team utilizes state-of-the-art technologies and innovative methodologies to advance medicines into the clinic. The successful candidate is expected to contribute to the discovery, research, and development of novel immunotherapeutic agents to address unmet medical needs of cancer patients. S/he/they will have opportunities for career growth through acquisition of new skills and professional relationships in a fast-paced and resource-rich environment.

Top three skills required:

• Human and mouse primary immune cell isolation and functional assays (T cells in particular)
• Immune cell gene editing (e.g., CRISPR-Cas9, lentivirus, transposase-based systems)
• Multi-color flow cytometry, including panel design, sample processing, and data acquisition

Key Responsibilities

• Independently execute in vitro and in vivo immunological assays, with study design, data analysis, and interpretation conducted under scientific guidance to support drug candidate initiation and advancement.
• Proactively evaluate new technologies and develop new assays to accelerate early-stage discovery activities and/or enhance our understanding of disease mechanisms
• Manage multiple projects simultaneously and work cross-functionally with colleagues in the oncology, protein engineering, chemistry, translational medicine, biomarker and clinical groups
• Presents research findings and recommendations to senior staff and contribute to preparation of research reports, manuscripts, INDs, and patent filings

Knowledge, Experience and Skills

• Master's degree with 5+ years of experience, or Bachelor's degree with 8+ years of experience in immunology, immuno-oncology, cell biology, molecular biology, or biochemistry in industry or academia.
• Direct experience in research drug discovery and target identification/validation in oncology or immuno-oncology is highly desirable.
• Solid understanding of fundamental immunology concepts, including innate and adaptive immunity, antigen presentation, cytokine signaling, and immune regulation.
• Proficiency in primary T cell-based functional assays such as activation, proliferation and cytotoxicity.
• Experience in conducting and optimizing cell-based assays, as well as performing studies to assess immune responses in human and animal models (including whole blood, PBMCs, and various primary cell subsets).
• Hands-on experience in general molecular and cell biology methods, including mammalian cell culture, multi-color flow cytometry, western blot, ELISA/Luminex/MSD, and CRISPR technology.
• Highly organized, with demonstrated rigor in documenting experimental design, execution, and data analysis.
• Excellent written and verbal communication skills, with the ability to work effectively in a collaborative, cross-functional environment.