Senior Scientist I/II, NMR Biophysics

Initial Therapeutics, Inc.; North Chicago (IL); On-site; USD 80,000 - 100,000; Full time

Job summary

A leading company in the biopharmaceutical sector is seeking a talented scientist with expertise in protein NMR spectroscopy to join their Biophysics team. The role involves driving projects in drug discovery using advanced NMR techniques. Ideal candidates will have extensive hands-on experience with high-resolution NMR spectroscopy and strong collaborative skills. The position offers opportunities for impactful research and collaboration across various functions within the organization.

Benefits

Paid Time Off

Medical/Dental/Vision Insurance

401(k) Plan

Short-term Incentive Programs

Long-term Incentive Programs

Qualifications

• At least 2 years of relevant academic or industry experience required.
• Extensive experience in high-resolution NMR spectroscopy including design and troubleshooting.

Responsibilities

• Design and implement NMR experiments for ligand binding evaluation.
• Process and analyze NMR screening data and structural NOE data.
• Present results at internal and external scientific meetings.

Skills

Collaboration

Communication

Detail Orientation

Education

PhD in Chemistry

PhD in Biochemistry

PhD in Biophysics

Tools

NMR Spectroscopy

Scripting Languages

Job description

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

Job Description

Job Description:

AbbVie is looking for a talented scientist with strong expertise in protein NMR spectroscopy to join our Lake County, Illinois, Biophysics team. This scientist, using NMR spectroscopy and computational methods will play a central role in the discovery and advancement of small molecule-based therapeutics across a variety of disease areas. As an integral member of our team, you will drive projects and collaborate across various functions within our Discovery organization. The ideal candidate should have extensive hands-on experience with high-resolution NMR spectroscopy including design, set-up, troubleshooting, and interpretation of 1D, 2D, and 3D experiments along with solid understanding of spectrometer hardware. Experience with NMR-based fragment screening, including protein sample optimization, collection of 1D and 2D NMR screening data, and use of ligand-induced chemical shift perturbations and protein-ligand NOE data to dock fragments into protein binding sites would be a plus. Success in this position will require both strong collaborative skills and excellent communication skills.

Key Responsibilities:

• Design and implement NMR experiments (1D and 2D) for evaluation of ligand binding to protein targets and for fragment screening of protein targets
• Set-up NMR spectrometer for the collection of protein-ligand NOE data to enable ligand docking
• Process and analyze NMR screening data and structural NOE data
• Employ computational methods for CSP/NOE-guided docking of ligands into protein binding sites
• Set-up and troubleshoot 1D, 2D, and 3D experiments taken from the literature
• Prepare protein samples for NMR-based studies, including buffer optimization
• Work with AbbVie personnel and vendors, when necessary, to maintain and repair spectrometers
• Maintain accurate and timely records of experimental results
• Interact with other members of the Biophysics Drug Discovery team to evaluate where NMR methods can be most effectively employed
• Present results at internal meetings
• Present results at external scientific meetings as appropriate
• Publish experimental results in peer-reviewed journals as appropriate
• Work closely with project teams to identify and solve key questions within the domain of small molecule drug discovery

Qualifications

Education/Experience:

Job grade, level, and title will be determined by the selected candidates credentials, education, and experience.

• PhD in Chemistry, Biochemistry, Biophysics, or a related field
• At least 2 years of relevant academic or industry experience is required
• Extensive experience in high-resolution NMR spectroscopy, including design, set-up, troubleshooting, and interpretation of 1D, 2D, and 3D experiments
• Scripting languages and pulse sequence programing ability would be a plus
• Must be detail oriented and meticulous regarding documentation and data management
• Ability to work both independently and as part of a highly collaborative, interdisciplinary team
• Effective written and verbal communication skills
• Ability to work on multiple projects in parallel and rapidly adjust to changing priorities

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible to participate in our short-term incentiveprograms.

• This job is eligible to participate in our long-term incentiveprograms

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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