Senior Scientist: High-Throughput Protein Binder Discovery

Amgen Inc. (IR); South San Francisco (CA); On-site; USD 131,000 - 177,000; Full time

Job summary

Amgen is seeking a Senior Scientist - Experimental Protein Design for Target Discovery to lead high-throughput binder generation and translate designs into minibinders and antibodies across diverse targets. You will build scalable binder libraries for multiplexed screening and provide tool reagents for early-stage target characterization.

The role requires a PhD with protein engineering expertise, hands-on experience in protein expression/purification and characterization, and cross-functional

Qualifications

• Ph.D. in Biochemistry, Protein Engineering, Bioengineering, Structural Biology, or a related field plus relevant postdoctoral experience.
• Demonstrated experience in expression, purification, and biochemical/biophysical characterization of engineered proteins (antibodies, minibinders, or designed scaffolds).
• Experience with multiple expression hosts (cell-free, E. coli, mammalian).

Responsibilities

• Translate designs into experimentally testable minibinders and antibodies across multiple targets in parallel.
• Lead high-throughput workflows for binder expression, purification, and characterization.
• Develop binder library production workflows and cellular assays for evaluation.
• Format de novo binders into multispecific modalities to test biological hypotheses.
• Analyze data to guide iterative design-build-test cycles.

Skills

Protein engineering

Biochemistry

Molecular biology

High-throughput screening

Antibodies

Computational design

Education

PhD in Biochemistry or related field

Tools

Flow cytometry

SPR

Cell culture

E. coli expression

Mammalian expression

Job description

Amgen is seeking a Senior Scientist - Experimental Protein Design for Target Discovery to lead high-throughput binder generation and translate designs into minibinders and antibodies across diverse targets. You will build scalable binder libraries for multiplexed screening and provide tool reagents for early-stage target characterization.

The role requires a PhD with protein engineering expertise, hands-on experience in protein expression/purification and characterization, and cross-functional