Senior Scientist, Microfluidic High-Throughput Screening

Ampersand; Boston (MA); On-site; USD 126,000 - 159,500; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Ampersand Biomedicines is seeking a Senior Scientist I to build and apply cell-based, high-throughput capabilities for engineered antibody and protein variant library screening in a fast-paced biotech environment.

The role interfaces molecular biology, cell biology, and microfluidics, requiring hands-on leadership in developing new biological systems and integrating assays into robust platform workflows for discovery. Boston location.

Qualifications

• PhD or MS with relevant industry experience
• Hands-on experience with mammalian cell culture and assays
• Experience leading development of biological assays, preferably high-throughput
• Knowledge of antibody biology or protein engineering
• Ability to design experiments, troubleshoot, and interpret data
• Experience with fluorescence-based detection platforms such as flow cytometry or microscopy

Responsibilities

• Collaborate with molecular biology scientists to define vector designs and assay-readiness criteria
• Establish workflows for transfecting, expanding, and selecting library cell populations
• Lead development and optimization of droplet-compatible assays for high-throughput screening
• Develop pathway-responsive reporter-cell assays for functional screening
• Optimize assay performance for robustness, sensitivity, reproducibility, and scalability
• Partner with microfluidics engineers to integrate assays into screening workflows
• Analyze and interpret data to guide assay optimization and platform development
• Document workflows and communicate findings across cross-functional teams

Skills

Mammalian cell culture

Transfection workflows

Cell-based assay execution

Flow cytometry / FACS

Analytical data interpretation

Antibody biology / protein engineering

Education

PhD in Cell Biology or related field

MS with substantial industry experience

Tools

Droplet microfluidics

High-throughput screening platforms

Microscopy

Job description

Ampersand Biomedicines is seeking a Senior Scientist I to build and apply cell-based, high-throughput capabilities for engineered antibody and protein variant library screening in a fast-paced biotech environment.

The role interfaces molecular biology, cell biology, and microfluidics, requiring hands-on leadership in developing new biological systems and integrating assays into robust platform workflows for discovery. Boston location.