Senior Scientist I — Antibody Engineering & Discovery Lead

BigHat Biosciences; San Mateo (CA); On-site; USD 160,000 - 185,000; Full time

Benefits offered by this job

Bonus

Stock options

Benefits

Job summary

BigHat Biosciences is seeking a Senior Scientist I to lead the antibody engineering and binder generation program, driving discovery, design, optimization, and characterization with internal and external partners.

You will guide rapid, iterative optimization and leverage both experimental and computational approaches to reach high-value therapeutic antibodies while communicating progress to stakeholders.

Qualifications

• Ph.D. required with at least 5+ years of industry research experience.
• Hands-on protein engineering expertise including design and optimization.
• Experience with diverse antibody formats (multispecifics, T-cell engagers, ADCs, etc.).
• Expertise in mammalian cell culture, immunoassays, and protein characterization.
• Strong data analysis, interpretation skills, and ability to communicate results.

Responsibilities

• Lead cross-functional project teams (Data Science, AI/ML, Engineering, Protein Sciences, Automation) to optimize antibodies.
• Understand target biology to design antibodies meeting candidate profiles.
• Apply antibody engineering approaches (humanization, liability remediation, affinity tuning, format engineering) to generate optimized antibodies.
• Collaborate with leadership to align strategy, research, and development.
• Perform in-depth data analysis of design cycles to leverage experimental and computational data.
• Regularly communicate results to decision makers and external partners.

Skills

Industry experience

Protein engineering

Antibody formats

Mammalian cell culture

Data analysis

Communication skills

Education

Ph.D. in biochemistry/structural biology/protein engineering

Job description

BigHat Biosciences is seeking a Senior Scientist I to lead the antibody engineering and binder generation program, driving discovery, design, optimization, and characterization with internal and external partners.

You will guide rapid, iterative optimization and leverage both experimental and computational approaches to reach high-value therapeutic antibodies while communicating progress to stakeholders.