Senior Research Associate - High-Throughput Protein Screening

Digital Biology; Watertown (MA); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Equity compensation

Medical, dental, and vision coverage

Flexible paid time off

Job summary

Digital Biology, located in Watertown, MA, seeks a Senior Research Associate to execute and scale high-throughput protein binder screening campaigns. You will manage core experimental workflows for external partners and ensure data quality for AI-driven protein design models.

This hands-on role requires executing scaled, multi-step assays with precision, maintaining rigorous documentation, and collaborating across protein engineers, molecular biologists, automation engineers, and computational

Qualifications

• BS, MS, or equivalent experience in protein biochemistry, molecular biology, biological engineering, or related field.
• Experience with high-throughput assays and strong molecular biology fundamentals.
• Ability to troubleshoot complex, multi-step workflows; comfortable with automation.
• Interest in laboratory automation and scalable experimental workflows.

Responsibilities

• Execute end-to-end high-throughput display campaigns including library prep, production, selection, amplification, and sequencing prep.
• Manage concurrent partner campaigns to meet timelines, quality standards, and deliverables.
• Optimize steps within workflows to improve throughput, reproducibility, cost, and turnaround time.
• Maintain documentation, sample traceability, and standardized procedures.
• Collaborate with computational teams to structure data/metadata for downstream analysis.
• Work with automation engineers to optimize robotic liquid-handling workflows.
• Communicate campaign progress, results, risks, and recommendations to stakeholders.

Skills

Protein biochemistry

Molecular biology

Biological engineering

High-throughput assays

Laboratory automation

Education

BS/MS or equivalent in related field

Tools

Automated liquid handling

NGS library preparation

Job description

Digital Biology, located in Watertown, MA, seeks a Senior Research Associate to execute and scale high-throughput protein binder screening campaigns. You will manage core experimental workflows for external partners and ensure data quality for AI-driven protein design models.

This hands-on role requires executing scaled, multi-step assays with precision, maintaining rigorous documentation, and collaborating across protein engineers, molecular biologists, automation engineers, and computational