Senior Scientist: Display Platforms & Directed Evolution

Future Ventures; Berkeley (CA); On-site; USD 140,000 - 190,000; Full time

Benefits offered by this job

Health benefits

Stock options

Winter shutdown

Job summary

Prellis Biologics is seeking a Principal Associate Scientist to lead display platform campaigns and directed evolution for antibody discovery. You will collaborate with data science to optimize designs and accelerate hit-to-lead transitions, driving high-throughput discovery in a cross-functional team.

The role requires hands-on lab work across yeast, phage, mammalian, and ribosome displays, with an emphasis on library design, screening, and affinity maturation.

Qualifications

• Scientist (PhD + 2+ years relevant industry experience) or Principal Associate Scientist (BSc/MSc + 5+ years direct relevant industry experience) in molecular/cell biology, biochemistry, immunology, or related discipline.
• Hands-on experience developing and deploying display platforms for antibody discovery and improvement.
• Hands-on experience scoping, designing, and constructing diversity libraries for antibody engineering.

Responsibilities

• Scope, build, deploy, and execute display and directed evolution campaigns for hit discovery, enrichment, and affinity maturation of lead molecules.
• Lead the design and sourcing of diversity libraries for display campaigns in collaboration with internal teams.
• Deploy and scale automation to accelerate display campaigns and library QC.
• Partner with Data Science/AI for library design and hit-to-lead optimization.
• Work with Antibody Protein Engineering for lead-molecule optimization.

Skills

Display platforms

Directed evolution

Antibody discovery

Molecular biology

Biochemistry

Immunology

Cloning

Flow cytometry

Biophysical assays

Data analysis

Education

PhD in related field

BSc/MSc in related field

Tools

Yeast display

Phage display

Mammalian display

Ribosome display

Job description

Prellis Biologics is seeking a Principal Associate Scientist to lead display platform campaigns and directed evolution for antibody discovery. You will collaborate with data science to optimize designs and accelerate hit-to-lead transitions, driving high-throughput discovery in a cross-functional team.

The role requires hands-on lab work across yeast, phage, mammalian, and ribosome displays, with an emphasis on library design, screening, and affinity maturation.