Antibody Discovery Scientist: Yeast Display & Lead Optimization

BioPhase; Pasadena (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

BioPhase in Pasadena, CA is seeking a highly motivated Scientist to join the Antibody Discovery team for biologic candidates. This full-time on-site role requires hands-on yeast display and in vitro antibody discovery experience, with collaboration across functions in a fast-paced research environment.

The ideal candidate will optimize yeast-display platforms, design and build antibody libraries, and conduct display campaigns to identify novel hits.

Qualifications

• Ph.D. in a relevant scientific field with at least 3 years of post-graduate laboratory experience.
• Hands-on yeast display experience including library construction.
• Experience with antibody lead optimization (affinity, potency, developability).
• Molecular cloning and DNA analysis skills (Geneious Prime, Sequencher or equivalents).
• Experience with NGS including library generation, QC, sequencing, and analysis.
• Strong understanding of antibody structure, function, and engineering.
• Proficiency with Microsoft Office and scientific data analysis tools.

Responsibilities

• Perform yeast display-based discovery screens to support new and ongoing therapeutic programs.
• Use NGS for library generation, QC, sequencing, and data analysis to support hit selection.
• Execute display-based lead optimization, including design, construction, QC, and screening of new display libraries.
• Review scientific data in real time and adjust experiments as needed to support discovery campaigns.
• Coordinate with cross-functional teams to prioritize critical experiments and advance discovery programs.
• Participate in group and departmental meetings and present data as needed.
• Maintain laboratory operations, including equipment, inventories, reagents, and supplies.
• Contribute to experiment design, data analysis, interpretation, reporting, and record keeping.

Skills

Yeast display

Antibody lead optimization

NGS data analysis

Molecular cloning

Data interpretation

MS Office

Education

Ph.D. in a relevant scientific field

Tools

Geneious Prime

Sequencher

Job description

BioPhase in Pasadena, CA is seeking a highly motivated Scientist to join the Antibody Discovery team for biologic candidates. This full-time on-site role requires hands-on yeast display and in vitro antibody discovery experience, with collaboration across functions in a fast-paced research environment.

The ideal candidate will optimize yeast-display platforms, design and build antibody libraries, and conduct display campaigns to identify novel hits.