Senior Scientist, Brain Delivery Antibody Shuttles

Harvard University FAS Human Resources; Boston (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Generous paid time off including oneal

Tuition assistance and reimbursement

Commuter benefits, discounts andCampus

Job summary

Wyss Institute at Harvard University seeks a talented scientist to lead development and characterization of antibody brain shuttle compounds, optimizing shuttles for specific payloads in neurodegenerative diseases. Work with in vitro cellular systems and humanized mouse models to define brain PK/PD and biophysical properties.

You will collaborate with the Brain Targeting Program (BTP), mentor technicians, and drive projects from concept through validation in vivo, advancing a robust modular

Qualifications

• Bachelor’s degree in neuroscience, biology, molecular biology, biochemistry, or related field.
• Minimum 5 years of experience with cell culture, rodent handling, protein/antibody analytics, and molecular and cellular biology techniques such as ELISA, western blotting, confocal imaging, FACS, or related experience.

Responsibilities

• Independently develop, validate, and perform protocols including confocal microscopy, flow cytometry, cell-based assays, plate-based ELISA assays, and others
• Present data at internal and external meetings; mentor and train less experienced technicians, academic trainees, and others
• Lead vitro and in vivo validation of antibody shuttles, using protein and cell binding assays, and in vivo brain and blood PK/PD studies in mouse models
• In vivo procedures include tail-vein intravenous injection, tissue harvesting (brain, blood and peripheral tissues) and lysate preparation
• Perform ELISAs using various samples; analyze and summarize data timely and accurately
• Conduct biophysical characterization of antibodies, including affinity determination with SPR, BLI, and stability and purity assessment

Skills

Collaborative problem solving

Team mentorship

Education

Bachelor’s degree neuroscience, biology, molecular biology, biochemistry, or related field

PhD strongly preferred in neuroscience, biology, molecular biology, biochemistry or related field

Job description

Wyss Institute at Harvard University seeks a talented scientist to lead development and characterization of antibody brain shuttle compounds, optimizing shuttles for specific payloads in neurodegenerative diseases. Work with in vitro cellular systems and humanized mouse models to define brain PK/PD and biophysical properties.

You will collaborate with the Brain Targeting Program (BTP), mentor technicians, and drive projects from concept through validation in vivo, advancing a robust modular