Senior Scientist, Antibody Brain Shuttles

Harvard University; Boston (MA); On-site; USD 140,000 - 200,000; Full time

Job summary

Harvard University is seeking a talented scientist to lead development and characterization of antibody brain shuttle compounds. You will work with the Brain Targeting Program (BTP) using in vitro systems and humanized mouse models to determine brain PK/PD and biophysical properties.

The role advances a modular brain delivery platform for large-molecule therapeutics in neurodegenerative diseases. You will collaborate with diverse scientists, mentor technicians, and drive projects from bench to

Qualifications

• Bachelor's degree in neuroscience, biology, molecular biology, biochemistry, or related field.
• PhD strongly preferred in neuroscience, biology, molecular biology, biochemistry or related field.
• Industry experience preferred.

Responsibilities

• Independently develop, validate, and perform various protocols including confocal microscopy, flow cytometry, cell-based assays, ELISA, and others.
• Present data at internal and external meetings; mentor and train less experienced technicians and students.
• Lead in vitro and in vivo validation of antibody shuttles, including PK/PD studies in mouse models; assess brain and blood pharmacokinetics.
• Lead projects to engineer and optimize shuttles for specific payloads to treat brain diseases.
• Perform lab maintenance and collaborate with a multidisciplinary team.

Skills

Cell culture

Rodent handling

Protein analytics

ELISA

Western blot

FACS

Confocal microscopy

Flow cytometry

Education

Bachelor's degree in neuroscience/biology/biochemistry

PhD strongly preferred

Tools

SPR

BLI

SEC

Job description

Harvard University is seeking a talented scientist to lead development and characterization of antibody brain shuttle compounds. You will work with the Brain Targeting Program (BTP) using in vitro systems and humanized mouse models to determine brain PK/PD and biophysical properties.

The role advances a modular brain delivery platform for large-molecule therapeutics in neurodegenerative diseases. You will collaborate with diverse scientists, mentor technicians, and drive projects from bench to