Senior Scientist II, Biotransformation and Disposition

SmartRecruiters, Inc.; North Chicago (IL); Vor Ort; USD 110.000 - 209.000; Vollzeit

Benefits dieser Stelle

Paid time off

401(k) plan

Long-term incentives

Health insurance

Zusammenfassung

AbbVie is seeking a Senior Scientist II to support drug discovery and development through design, execution, and interpretation of biotransformation and ADME studies. You will apply mass spectrometry, LC-MS/MS, and structure elucidation to answer key scientific questions and guide project strategy.

The role requires hands-on laboratory work, collaboration across disciplines, and the ability to communicate complex data to management and regulatory teams.

Qualifikationen

• PhD in Chemistry, Life Sciences or related field with 4+ years; MS with 8+ years; or BS with 10+ years of relevant experience.
• Strong expertise in mass spectrometry, LC-MS, and metabolite profiling.
• Experience leading cross-functional teams and communicating across project teams.

Aufgaben

• Design, conduct and report in vitro and in vivo biotransformation studies to identify metabolites and clearance mechanisms.
• Perform metabolite profiling and structural elucidation using LC-MS/MS and high‑resolution MS.
• Develop and troubleshoot chromatographic and MS methods, including radiolabeled assays where applicable.
• Integrate metabolite data with DMPK/ADME/PK data to guide compound selection and development.
• Mentor colleagues, drive innovation, and ensure rigorous data documentation and regulatory compliance.

Kenntnisse

Mass spectrometry

Biotransformation

Project collaboration

Mentoring

Communication

Ausbildung

PhD in Chemistry or Life Sciences

Advanced degree (MS or equivalent)

Tools

Thermo/Sciex MS instruments

LC-MS/MS

Mass spec software

Jobbeschreibung

Senior Scientist II, Biotransformation and Disposition

• Full-time
• Salary Min: 109500
• Salary Max: 208500
• Workday Global Grade: 18
• Compensation: USD 109,500 - USD 208,500 - yearly

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

The Biotransformation and Disposition team within AbbVie’s Quantitative Translational and ADME Sciences organization is seeking a driven Senior Scientist II to support AbbVie’s drug discovery and development programs through the design, execution, interpretation, and communication of in vitro and in vivo biotransformation and ADME studies. The successful candidate will apply expertise in drug metabolism, metabolite profiling, mass spectrometry, liquid chromatography, and structure elucidation to answer key scientific questions, guide project strategy, and advance compounds across the pipeline. This role requires strong scientific judgment, hands-on laboratory capabilities, cross-functional collaboration, and the ability to translate complex analytical data into clear conclusions for project teams, management, and regulatory submissions. Duties will be focused on laboratory work, and the applicant will collaborate across various disciplines within AbbVie. Additional expertise in peptide chemistry, structural elucidation, and mass spectrometry is preferred.

Key responsibilities and desired skills include:

• Design, conduct, interpret, and report in vitro and in vivo biotransformation studies to identify metabolites, metabolic pathways, and clearance mechanisms.
• Perform metabolite profiling and structural elucidation using LC-MS/MS, high-resolution mass spectrometry, and complementary analytical techniques.
• Develop, optimize, maintain, and troubleshoot chromatographic and mass spectrometric methods, including assays involving radiolabeled compounds where applicable.
• Integrate metabolite data with broader DMPK, ADME, pharmacokinetic, toxicology, chemistry, and clinical findings to support compound selection and development decisions.
• Represent Biotransformation and Disposition on cross-functional project teams and communicate scientific findings through presentations, technical reports, publications, and regulatory documents.
• Evaluate and implement emerging technologies, study designs, automation approaches, and analytical methods to improve data quality, sensitivity, throughput, and scientific impact.
• Collaborate effectively with internal and external partners while maintaining rigorous documentation, data integrity, regulatory compliance, and laboratory safety standards.
• Contribute to a collaborative learning environment by mentoring colleagues, sharing technical expertise, encouraging innovation, and supporting continuous improvement.

Additional preferred skills:

• Design and interpret peptide biotransformation experiments to identify enzymatic cleavage sites, metabolic pathways, and structural modifications across relevant in vitro and in vivo systems.
• Apply expertise in peptide mass spectrometry, including LC-MS/MS and high-resolution MS, to characterize intact peptides, metabolites, and degradation products in biotransformation studies.
• Specific hands-on expertise in handling high-end high-resolution Thermo and Sciex mass spectrometers and software are desired.

• Ph.D. in Chemistry, Life Sciences or a related field with 4+ years; alternatively, a Master’s degree with 8+ years or a Bachelor’s degree with 10+ years of relevant academic or industry research experience in small-molecule drug development.
• Demonstrated expertise in mass spectrometry, liquid chromatography, structure elucidation, core DMPK processes, including analytical method development, metabolite profiling, and biotransformation.
• Strong written (peer reviewed publications), verbal, presentation, interpersonal, and collaborative skills, with the proven ability to work independently and effectively across multidisciplinary teams.
• Proven leadership capabilities, including mentoring others, fostering a learning environment, driving innovation, building strong cross-functional relationships, and continuously raising scientific and performance standards.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: