Senior Scientist: Bioreactor Modelling & Digital Twins

Sanofi; Framingham (MA); On-site; USD 101,000 - 145,000; Full time

Benefits offered by this job

Shuttle service

Job summary

Sanofi in Framingham, MA is seeking a Senior Scientist - Process Modelling to develop and validate bioreactor dynamic models for recombinant protein production and product quality attributes. You will deploy models in manufacturing and work with cross-functional teams across R&D and Manufacturing.

Ideal candidates hold a PhD or Master’s in a related field with experience in dynamic modeling and proficiency in Python, MATLAB, R or Julia. Strong communication and collaboration skills are essential.

Qualifications

• PhD in Chemical Engineering, Biochemical Engineering, Process Systems Engineering, Bioengineering, Biomedical Engineering, or related engineering or scientific discipline
• OR Master’s degree in any of the above fields

Responsibilities

• Develop, calibrate, and validate bioreactor dynamic models to simulate, optimize, and control recombinant protein production and product quality attributes
• Transfer and deploy bioreactor models in a commercial manufacturing environment to support process monitoring and forecasting (digital shadows) and/or real-time bioreactor optimization and control (digital twins)
• Work as part of matrix project teams with cell-culture development, process development, analytical, automation, and data science teams across R&D and Manufacturing.
• Communicate model assumptions, uncertainty, limitations, and process interpretation to technical and non-technical stakeholders
• Maintain reproducible computational workflows using appropriate coding, documentation, version control, and data-management practices
• Act as a change agent to support the implementation of process modeling in established cell culture process development workflows
• Document progress against deliverables with rigorous scientific communication via technical presentations, reports and, when appropriate, scientific publications

Skills

Bioreactor modeling

Python

MATLAB

R

Julia

Education

PhD in Chemical Engineering / related field

Masters in Chemical/Process Engineering or related field

Job description

Sanofi in Framingham, MA is seeking a Senior Scientist - Process Modelling to develop and validate bioreactor dynamic models for recombinant protein production and product quality attributes. You will deploy models in manufacturing and work with cross-functional teams across R&D and Manufacturing.

Ideal candidates hold a PhD or Master’s in a related field with experience in dynamic modeling and proficiency in Python, MATLAB, R or Julia. Strong communication and collaboration skills are essential.