Senior Scientist, Antibody Discovery & Protein Engineering

Raven (RA Ventures); Boston (MA); Hybrid; USD 110,000 - 160,000; Full time

Benefits offered by this job

Annual bonus

Long-term incentives

Hybrid schedule

Job summary

Raven is seeking a Senior Scientist to join our Protein Engineering and Discovery Biology group at our Cambridge, MA headquarters on a hybrid schedule.

You will design and run in vitro and cell-based assays for antibody candidates, generate data, and collaborate across teams to advance discovery programs. The role requires PhD-level expertise and hands-on experience with antibody analytics and cell culture.

Qualifications

• PhD in Immunology, Biochemistry, Molecular/Cell Biology, Protein Science, Bioengineering, or related field with 2–5 years industry experience.
• Hands-on experience with antibody assays such as ELISA, SPR, BLI, and/or flow cytometry.
• Experience developing or running cell-based internalization assays.
• Experience with cell-based assays evaluating antibody internalization, receptor dynamics, and downstream signaling.
• Strong mammalian cell culture skills and aseptic technique; experience generating and characterizing cell lines.
• Practical experience with signaling assay formats and protein analytical techniques.
• Strong analytical, organizational, and communication skills for cross-functional teams.

Responsibilities

• Design, execute, and interpret antibody binding assays (ELISA, SPR, BLI, flow cytometry).
• Develop and run cell-based internalization assays to assess trafficking and uptake.
• Design and execute cell-based functional assays including dose-response and mechanism-of-action studies.
• Maintain and expand mammalian cell culture capabilities and engineered cell lines.
• Perform cell line characterization and expression profiling to support assays.
• Develop and execute cell signaling assays to evaluate antibody pharmacology.
• Conduct protein analytics (SEC-HPLC, SDS-PAGE) for characterization and quality.

Skills

Antibody assays

Cell-based assays

Mammalian cell culture

Data analysis

Independent thinking

Education

PhD in Immunology/Biochemistry/Molecular/Cell Biology

Tools

ELISA

SPR

BLI

Flow cytometry

Job description

Raven is seeking a Senior Scientist to join our Protein Engineering and Discovery Biology group at our Cambridge, MA headquarters on a hybrid schedule.

You will design and run in vitro and cell-based assays for antibody candidates, generate data, and collaborate across teams to advance discovery programs. The role requires PhD-level expertise and hands-on experience with antibody analytics and cell culture.