Senior Research Associate, Analytical Development

Systimmune; Bothell (WA); On-site; USD 70,000 - 90,000; Full time

Benefits offered by this job

Health benefits

401(k) with company match

PTO 15 days

Paid holidays

Job summary

SystImmune, based in Bothell, WA, is seeking a Senior Research Associate in Analytical Development to characterize antibody-based therapeutics. You will execute, troubleshoot, and optimize analytical methods (UPLC, CE, binding assays) in a high-throughput environment and contribute to early- to mid-stage development.

This onsite role requires a BS/MS with 3–5 years in biotech/pharma, hands-on experience with HPLC/UPLC and antibody binding assays, and strong documentation and teamwork skills.

Qualifications

• BS with 5+ years in biotech/pharma biologics analytical development or related lab function.
• MS with 3+ years in biotech/pharma analytical development or related lab function.

Responsibilities

• Execute analytical methods using UPLC (SEC, IEX, RP), CE (CE-SDS, cIEF), and binding assays to support antibody characterization.
• Support method optimization and qualification activities under guidance of senior scientists.
• Generate data for cell line development, process development, formulation screening, comparability, and stability studies.
• Maintain documentation in electronic lab notebooks and data systems per good documentation practices.
• Perform routine instrument maintenance and troubleshooting for UPLC, CE, plate readers, and BLI instruments.

Skills

UPLC

CE

Binding assays

HPLC/UPLC troubleshooting

Documentation

Team collaboration

Fast-paced environment

Education

BS with 5+ years

MS with 3+ years

Tools

Empower

SoftMax Pro

ForteBio Data Analysis

JMP

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

As a Senior Research Associate in Analytical Development, the incumbent will be a hands-on contributor to the characterization of antibody-based therapeutics. The Senior RA will execute, troubleshoot, and help optimize analytical methods for early- to mid-stage development, with a focus on UPLC, CE, and binding assays. This is a lab-centered role ideal for an experienced BS/MS-level scientist who is rigorous at the bench, thrives in a dynamic, high-throughput setting, and wants to grow into method development and ownership of analytical workflows.

This is an onsite position in Bothell, WA.

Key Responsibilities

• Independently execute analytical methods using UPLC (SEC, IEX, RP), CE (CE-SDS, cIEF), and binding assays (ELISA, BLI) to support antibody characterization, with a high standard of accuracy and reproducibility.
• Support method optimization and qualification activities under the guidance of senior scientists, and contribute to the development of new methods as needs arise.
• Generate data for cell line development, process development, formulation screening, comparability, and stability studies, and manage sample tracking and testing schedules.
• Process, analyze, and summarize data; perform first-pass interpretation and flag unexpected results or trends to project scientists in a timely manner.
• Maintain accurate, complete, and timely documentation in electronic lab notebooks and data systems in line with good documentation practices.
• Perform routine instrument maintenance, calibration checks, and basic troubleshooting for UPLC, CE, plate readers, and BLI instruments; coordinate service and preventive maintenance.
• Prepare reagents, buffers, reference standards, and critical materials; manage inventory and ordering for the analytical lab.
• Draft method protocols, data summaries, and sections of technical reports for review by senior scientists.
• Collaborate with upstream, downstream, and formulation team members in an integrated CMC environment.
• Contribute to building the analytical lab infrastructure as the company scales, including evaluating new consumables, templates, and workflows.

Qualifications

• BS with 5+ years or MS with 3+ years of relevant industry experience (biotech/pharma) in biologics analytical development or a closely related laboratory function.
• Strong hands-on proficiency with HPLC/UPLC (SEC, IEX, or RP) and/or CE (CE-SDS, cIEF) for therapeutic proteins, including routine troubleshooting.
• Hands-on experience with antibody binding assays (e.g., ELISA, SPR, or BLI).
• Working knowledge of antibody structure, common post-translational modifications, and critical quality attributes (CQAs).
• Demonstrated attention to detail, strong organizational skills, and the ability to manage multiple studies in parallel with shifting priorities.
• Good written and verbal communication skills and a track record of effective teamwork.
• Comfortable working in a fast-paced, evolving environment and willing to take on new responsibilities.

Preferred:

• Prior experience in a GMP or QC release testing environment, or with method qualification and tech transfer.
• Familiarity with software platforms such as Empower, SoftMax Pro, ForteBio Data Analysis, or JMP.
• Passion for working in a mission-driven environment and building from the ground up.

Compensation and Benefits:

The expected base salary range for this position is $70,000 - $90,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.

While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.