Scientist, Protein Sciences

SystImmune, Inc.; Bothell (WA); On-site; USD 90,000 - 115,000; Full time

Benefits offered by this job

Premium medical/dental/vision benefits

Short-Term Disability (STD)

Long-Term Disability (LTD)

401(k) with 50% company match up to 3%

Five-year vesting

15 PTO days per year

Sick leave

11 paid holidays

Job summary

SystImmune, Inc. in Bothell, WA is seeking a Scientist for the Antigen Science team to design, express, and purify recombinant antigens that support antibody discovery and engineering programs.

You will work with mammalian expression systems (HEK293/CHO), optimize purification workflows, and collaborate across discovery and assay development to deliver high-quality reagents on schedule.

Qualifications

• PhD in Biochemistry, Molecular Biology, or a related field; 0-3 years of industry or postdoctoral experience for PhD candidates.
• Strong hands-on experience with recombinant protein purification technologies.
• Strong hands-on experience with molecular biology techniques, including plasmid construction, and sequence analysis.
• Experience with mammalian cell culture and recombinant protein expression, including transient transfection and stable cell line development.
• Ability to work independently and troubleshoot experimental problems.
• Clear written and verbal communication skills and a collaborative approach to cross-functional work.

Responsibilities

• Design and clone antigen constructs using molecular biology techniques, including vector design, cloning strategies, and sequence verification.
• Develop and optimize transient and stable mammalian expression systems (e.g., HEK293 or CHO) to produce secreted and cell-surface antigens.
• Establish and execute purification workflows for recombinant proteins, including affinity, ion-exchange, and size-exclusion chromatography.
• Troubleshoot expression and purification problems, adjusting constructs, culture conditions, and purification strategies as needed.
• Establish and execute quality control for each antigen batch, including purity, identity, and homogeneity.
• Partner with antibody discovery, engineering, and assay development colleagues to understand reagent requirements and deliver accordingly.
• Maintain detailed records, present results to the team and cross-functional partners, and contribute to technical reports, publications, and patent applications.

Skills

Protein purification

Molecular biology techniques

Mammalian cell culture

Transfection

Troubleshooting

Communication skills

Cross-functional collaboration

Education

PhD in Biochemistry, Molecular Biology, or related field

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

We are seeking a Scientist to join our Antigen Science team, where you will drive the design, expression, and purification of recombinant antigens that support antibody discovery and engineering programs. You will combine molecular biology expertise with mammalian expression know-how to produce high-quality reagents, and you will work closely with colleagues across discovery and assay development to make sure each antigen meets program needs. You will bring independent judgment to construct design, expression optimization, and purification challenges, and you will help the team move projects from hypothesis to usable reagents on schedule.

This position is full-time onsite in Bothell, WA.

Responsibilities

• Design and clone antigen constructs using molecular biology techniques, including vector design, cloning strategies, and sequence verification.
• Develop and optimize transient and stable mammalian expression systems (e.g., HEK293 or CHO) to produce secreted and cell-surface antigens.
• Establish and execute purification workflows for recombinant proteins, including affinity, ion-exchange, and size-exclusion chromatography.
• Troubleshoot expression and purification problems, adjusting constructs, culture conditions, and purification strategies as needed.
• Establish and execute quality control for each antigen batch, including purity, identity, and homogeneity.
• Partner with antibody discovery, engineering, and assay development colleagues to understand reagent requirements and deliver accordingly.
• Maintain detailed records, present results to the team and cross-functional partners, and contribute to technical reports, publications, and patent applications.

Qualifications

• PhD in Biochemistry, Molecular Biology, or a related field, with 0-3 years of industry or postdoctoral experience for PhD candidates.
• Strong hands‑on experience with recombinant protein purification technologies.
• Strong hands‑on experience with molecular biology techniques, including plasmid construction, and sequence analysis.
• Demonstrated experience with mammalian cell culture and recombinant protein expression, including transient transfection and stable cell line development.
• Demonstrated ability to work independently and troubleshoot experimental problems.
• Clear written and verbal communication skills and a collaborative approach to cross‑functional work.

Preferred Qualifications

• Experience with antibody discovery, immunization, or screening workflows.
• Experience with high‑throughput or automated expression and purification platforms.
• Publications in peer‑reviewed journals.

Compensation and Benefits

The expected base salary range for this position is $90,000 - $115,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.

While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.