Senior Research Associate, Protein Sciences

SystImmune, Inc.; Bothell (WA); On-site; USD 70,000 - 90,000; Full time

Benefits offered by this job

Premium medical/dental/vision coverage

401(k) with company match

PTO and holidays

Job summary

SystImmune, Inc. in Bothell, WA, is seeking a Senior Research Associate to join the Antigen Science team to support antibody discovery and assay development.

You will produce and QC antigens, including expression in mammalian cells and purification, to enable ongoing discovery projects. The role focuses on day-to-day production, plasmid DNA scale-up, and documentation, with a collaborative environment to keep reagents moving on schedule.

Qualifications

• BA in Biology, Biochemistry, Molecular Biology, or related field with 5+ years of industry experience in protein production, or MS in related field with 3+ years of industry experience.
• Hands-on experience with recombinant protein expression and purification, including mammalian cell culture and transient transfection.
• Practical experience with plasmid DNA preparation and scale-up.
• Proficiency with routine protein analysis, including SDS-PAGE and Western blotting.
• Working knowledge of chromatography, including affinity, ion-exchange, and size-exclusion, on FPLC or similar systems.
• Ability to manage multiple tasks and priorities in a fast-paced team environment.
• Clear written and verbal communication skills and a collaborative approach to cross-functional work.

Responsibilities

• Carry out antigen purification using affinity, ion-exchange, and size-exclusion chromatography on FPLC or similar systems, following established protocols.
• Scale up plasmid DNA preparations to support expression campaigns, ensuring quality and yield.
• Perform recombinant antigen expression in mammalian cells, including both transient and stable expression.
• Perform routine antigen quality control, including SDS-PAGE, Western blotting, and other standard analytical assays, and record and report results.
• Maintain detailed, accurate laboratory records, inventory, and reagent batch documentation.

Skills

Recombinant protein expression

Protein purification

Mammalian cell culture

Transfection

Plasmid DNA prep

SDS-PAGE

Western blot

Chromatography

Education

BA in Biology/Biochemistry/Molecular biology or related (5+ yrs)

MS in related field (3+ yrs)

Tools

FPLC

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are seeking a Senior Research Associate to join our Antigen Science team and serve as a core technical resource for the whole group. You will be responsible for the day-to-day production of antigens that support antibody discovery, engineering, and assay development, including antigen expression, purification, DNA scale-up, and routine quality control. You will execute established workflows reliably and with high quality, and you will help the team keep reagent production moving so that colleagues across discovery and assay development receive what they need on schedule.

This is onsite in Bothell, WA.

Responsibilities

• Carry out antigen purification using affinity, ion-exchange, and size-exclusion chromatography on FPLC or similar systems, following established protocols.
• Scale up plasmid DNA preparations to support expression campaigns, ensuring quality and yield.
• Perform recombinant antigen expression in mammalian cells, including both transient and stable expression,
• Perform routine antigen quality control, including SDS-PAGE, Western blotting, and other standard analytical assays, and record and report results.
• Maintain detailed, accurate laboratory records, inventory, and reagent batch documentation.

Qualifications

• BA in Biology, Biochemistry, Molecular Biology, or a related field with 5+ years of industry experience in protein production, or MS in a related field with 3+ years of industry experience.
• Hands-on experience with recombinant protein expression and purification, including mammalian cell culture and transient transfection.
• Practical experience with plasmid DNA preparation and scale-up.
• Proficiency with routine protein analysis, including SDS-PAGE and Western blotting.
• Working knowledge of chromatography, including affinity, ion-exchange, and size-exclusion, on FPLC or similar systems.
• Ability to manage multiple tasks and priorities in a fast-paced team environment.
• Clear written and verbal communication skills and a collaborative approach to cross-functional work.

Compensation and Benefits:

The expected base salary range for this position is $70,000 - $90,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.

While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.