Senior Biologics Engineer: Antibody Design

Biogen, Inc.; Cambridge (MA); Hybrid; USD 124,000 - 166,000; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

Vision Insurance

Paid Time Off

Job summary

Biogen Cambridge seeks a Sr. Scientist to advance biologics engineering and therapeutic discovery. You will design, express, and characterize recombinant proteins and antibodies from design through production, while leading external CRO collaborations and mentoring the team.

The role integrates hands-on biology with strategic project input, and requires strong communication as well as a track record of scientific achievement. Hybrid work arrangement available.

Qualifications

• Ph.D. in biochemistry or related field with 2+ years industry experience, or a Master’s degree with 6+ years relevant industry experience.
• Strong expertise in molecular biology and protein engineering, with demonstrated experience designing antibodies and novel antibody-based formats.
• Hands-on experience developing and expressing mammalian cell culture for antibody production.
• Experience in protein purification and in vitro analytical characterization (SEC, Octet).
• Experience characterizing antibody binding and target engagement using flow cytometry.

Responsibilities

• Design, engineer, and express recombinant proteins and antibodies including bispecifics and novel fusions.
• Develop stable CHO and mammalian cell lines to support discovery, screening, and lead optimization.
• Support protein purification and characterization, including binding assessments and cell-surface engagement.
• Manage all protein production activities at CROs and ensure timelines.
• Contribute to project strategy, present findings at team meetings, and document in ELN.
• Collaborate across multidisciplinary teams to advance the therapeutic pipeline.

Skills

Molecular Biology

Antibody Engineering

Protein Engineering

Mammalian Cell Culture

Flow Cytometry

CRO Management

Data Presentation

Team Collaboration

Education

Ph.D. in Biochemistry or related field

M.S. with 6+ years in industry

Tools

SEC

Octet

Job description

Biogen Cambridge seeks a Sr. Scientist to advance biologics engineering and therapeutic discovery. You will design, express, and characterize recombinant proteins and antibodies from design through production, while leading external CRO collaborations and mentoring the team.

The role integrates hands-on biology with strategic project input, and requires strong communication as well as a track record of scientific achievement. Hybrid work arrangement available.